Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, Bethesda, MD, USA.
Nat Immunol. 2018 Sep;19(9):906-907. doi: 10.1038/s41590-018-0193-0.
In the current issue of , Casanova and colleagues demonstrate that humans (and mouse models) with autosomal-recessive SPPL2a deficiency have a severe defect in conventional dendritic cell 2 survival and production of IL-12 and IL-23, and diminished IFN-γ secretion by mycobacterium-specific memory T cells, thus resulting in increased susceptibility to mycobacterial diseases.
在本期的 中，Casanova 及其同事证明，常染色体隐性 SPPL2a 缺陷的人类（和小鼠模型）存在常规树突状细胞 2 存活和 IL-12 和 IL-23 产生的严重缺陷，以及分枝杆菌特异性记忆 T 细胞 IFN-γ 分泌减少，从而导致对分枝杆菌病的易感性增加。
