University of Minnesota, Center for Immunology, Minneapolis, Minnesota 55414.
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a029132. doi: 10.1101/cshperspect.a029132.
Much of what we understand about immunology, including the response to vaccines, come from studies in mice because they provide many practical advantages compared with research in higher mammals and humans. Nevertheless, modalities for preventing or treating disease do not always translate from mouse to humans, which has led to increasing scrutiny of the continued merits of mouse research. Here, we summarize the pros and cons of current laboratory mouse models for immunology research and discuss whether overreliance on nonphysiological, ultra-hygienic animal husbandry approaches has limited the ultimate translation potential of mouse-derived data to humans. Alternative approaches are discussed that may extend the use of the mouse model for preclinical studies.
我们对免疫学的了解，包括对疫苗的反应，很大程度上来自于对老鼠的研究，因为与在高等哺乳动物和人类中的研究相比，老鼠研究具有许多实际优势。然而，预防或治疗疾病的方法并不总是能从老鼠身上转化到人类身上，这导致人们对继续进行老鼠研究的价值提出了越来越多的质疑。在这里，我们总结了当前免疫学研究中实验室老鼠模型的优缺点，并讨论了过度依赖非生理、超高洁净度的动物饲养方法是否限制了从老鼠身上获得的数据在人类身上的最终转化潜力。我们还讨论了一些可能扩展老鼠模型在临床前研究中应用的替代方法。
