Zhang Zhaoran, Wang Jinyan, Dong Xiang
Department of Gastroenterology, Jining First People's Hospital, Jining, Shandong 272000, P.R. China.
Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Oncol Lett. 2018 Sep;16(3):2857-2864. doi: 10.3892/ol.2018.9050. Epub 2018 Jun 28.
Wnt2 plays a pivotal role in human cancer. However, it is not yet known whether Wnt2 contributes to promoting migration and invasion of gastric cancer. The present study aimed to investigate the expression of Wnt2 in gastric cancer tissues and cell lines, and to analyze the effect of Wnt2 on gastric cancer cells. Wnt2 expression level was evaluated in gastric cancer samples and adjacent normal gastric tissues by immunohistochemical and western blot analysis. To investigate the effect of Wnt2 on gastric cancer cells, an Wnt2 secreting system was established using CHO cells. The results indicated that Wnt2 is overexpressed in gastric cancer and is implicated in metastasis and TNM stage. Additionally, the results of experiments demonstrated that Wnt2 contributes to enhancing the migration and invasion abilities of gastric cancer cells. These results suggested that Wnt2 may be an effective target of treatment for patients with advanced gastric cancer.
Wnt2在人类癌症中起着关键作用。然而，Wnt2是否有助于促进胃癌的迁移和侵袭尚不清楚。本研究旨在调查Wnt2在胃癌组织和细胞系中的表达，并分析Wnt2对胃癌细胞的影响。通过免疫组织化学和蛋白质印迹分析评估胃癌样本和邻近正常胃组织中Wnt2的表达水平。为了研究Wnt2对胃癌细胞的影响，使用CHO细胞建立了Wnt2分泌系统。结果表明，Wnt2在胃癌中过度表达，并与转移和TNM分期有关。此外，实验结果表明，Wnt2有助于增强胃癌细胞的迁移和侵袭能力。这些结果表明，Wnt2可能是晚期胃癌患者有效的治疗靶点。
