Li Yulong, Zeng Xiaoli, He Jianxun, Gui Yuan, Zhao Song, Chen Hua, Sun Qi, Jia Nan, Yuan Hui
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China.
Oncol Lett. 2018 Sep;16(3):4078-4084. doi: 10.3892/ol.2018.9125. Epub 2018 Jul 11.
Circular RNAs (circRNAs) may serve as biomarkers for a potentially non-invasive diagnosis of cancer. To understand their diagnostic performance, a systematic meta-analysis of the published literature was conducted to review the diagnostic efficiency of circRNAs in patients with cancer. Eligible studies published up to November 30, 2017, on PubMed and EMBASE, were selected for the meta-analysis. All studies were carefully and independently reviewed by two researchers based on their titles and abstracts, following which full texts were perused for potential eligibility. All statistical analyses were performed by STATA 13.0 statistical software and Meta-DiSc 1.4. A total of 10 eligible studies were included. The pooled diagnostic odds ratio was 7.265. The pooled sensitivity was 0.708 and the pooled specificity was 0.722. The positive likelihood and negative likelihood ratios were 2.483 and 0.372, respectively. The area under the curve was 0.793. circRNA was determined to be a notably effective assistant diagnostic biomarker for cancer.
环状RNA（circRNAs）可能作为癌症潜在无创诊断的生物标志物。为了解其诊断性能，我们对已发表文献进行了系统的荟萃分析，以评估circRNAs在癌症患者中的诊断效率。我们选取了截至2017年11月30日在PubMed和EMBASE上发表的符合条件的研究进行荟萃分析。两名研究人员根据标题和摘要对所有研究进行了仔细且独立的审查，随后阅读全文以确定其是否符合条件。所有统计分析均使用STATA 13.0统计软件和Meta-DiSc 1.4进行。共纳入10项符合条件的研究。合并诊断比值比为7.265。合并敏感性为0.708，合并特异性为0.722。阳性似然比和阴性似然比分别为2.483和0.372。曲线下面积为0.793。circRNA被确定为一种显著有效的癌症辅助诊断生物标志物。
