环状 RNA 在结直肠癌中的预后和诊断价值：一项荟萃分析。
Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis.
机构信息
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
出版信息
BMC Cancer. 2020 May 19;20(1):448. doi: 10.1186/s12885-020-06932-z.
BACKGROUND
Circular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNAs in colorectal cancer.
METHODS
The PubMed, Cochrane Library, and Web of Science online databases were searched for relevant studies before May 15, 2019. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between circRNAs expression, and overall survival (OS) and clinical parameters. Pooled sensitivity, specificity, and the area under the curve (AUC) were employed to assess the diagnostic value of circRNAs.
RESULTS
A total of 19 studies were enrolled in this meta-analysis, with 11 on clinicopathological parameters, 8 on prognosis and 7 on diagnosis. For clinicopathological and prognostic value, elevated expression of oncogenic circRNAs was correlated with poor clinical parameters (tumor size: OR = 1.769, 95% CI: 1.097-2.852; differentiation grade: OR = 1.743, 95% CI: 1.032-2.946; TNM stage: OR = 3.320, 95% CI: 1.529-7.207; T classification: OR = 3.410, 95% CI: 2.088-5.567; lymph node metastasis: OR = 3.357, 95% CI: 2.160-5.215; distal metastasis: OR = 4.338, 95% CI: 2.503-7.520) and worse prognosis (HR = 2.29, 95% CI: 1.50-3.52). However, elevated expression of tumor-suppressor circRNAs was correlated with better clinical parameters (differentiation grade: OR = 0.453, 95% CI: 0.261-0.787; T classification: OR = 0.553, 95% CI: 0.328-0.934; distal metastasis: OR = 0.196, 95% CI: 0.077-0.498) and favorable prognosis (HR = 0.37, 95% CI: 0.22-0.64). For diagnostic value, the pooled sensitivity, specificity, and AUC were 0.82 (95% CI, 0.75-0.88), 0.72 (95% CI, 0.66-0.78), and 0.82 (95% CI, 0.78-0.85), respectively.
CONCLUSIONS
These results indicate that circRNAs may be potential biomarkers for the diagnosis and prognosis of colorectal cancer.
背景
环状 RNA（circRNAs）是众多肿瘤中非编码 RNA 网络中的研究热点。本研究旨在评估 circRNAs 在结直肠癌中的临床病理、预后和诊断价值。
方法
检索了 2019 年 5 月 15 日前PubMed、Cochrane 图书馆和 Web of Science 在线数据库中的相关研究。使用合并的风险比（HRs）和比值比（ORs）及其 95%置信区间（CIs）评估 circRNAs 表达与总生存率（OS）和临床参数之间的相关性。采用合并的敏感性、特异性和曲线下面积（AUC）评估 circRNAs 的诊断价值。
结果
本荟萃分析共纳入 19 项研究，其中 11 项研究与临床病理参数有关，8 项研究与预后有关，7 项研究与诊断有关。对于临床病理和预后价值，致癌 circRNAs 的高表达与较差的临床参数有关（肿瘤大小：OR=1.769，95%CI：1.097-2.852；分化程度：OR=1.743，95%CI：1.032-2.946；TNM 分期：OR=3.320，95%CI：1.529-7.207；T 分类：OR=3.410，95%CI：2.088-5.567；淋巴结转移：OR=3.357，95%CI：2.160-5.215；远处转移：OR=4.338，95%CI：2.503-7.520），预后较差（HR=2.29，95%CI：1.50-3.52）。然而，肿瘤抑制 circRNAs 的高表达与更好的临床参数（分化程度：OR=0.453，95%CI：0.261-0.787；T 分类：OR=0.553，95%CI：0.328-0.934；远处转移：OR=0.196，95%CI：0.077-0.498）和有利的预后（HR=0.37，95%CI：0.22-0.64）有关。对于诊断价值，合并的敏感性、特异性和 AUC 分别为 0.82（95%CI，0.75-0.88）、0.72（95%CI，0.66-0.78）和 0.82（95%CI，0.78-0.85）。
结论
这些结果表明，circRNAs 可能是结直肠癌诊断和预后的潜在生物标志物。
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