Byzov A L, Shura-Bura T M
Vision Res. 1986;26(1):33-44. doi: 10.1016/0042-6989(86)90069-6.
In any chemical synapse there is an electrical feedback initiated by the electrical current generated by the postsynaptic neurone. We argue that this feedback can be rather effective in the case of invaginating synapses in the retina. A model of a dyad synapse (cone-horizontal cell-bipolar cell) is developed, in which the transfer function between the cone and bipolar cell is modulated by the synaptic current of the horizontal cell. This modulation originates by the change of the potential drop along the intercellular gap between the cone and the horizontal cell. The model takes into account the electrical coupling between the horizontal cells as well as the nonlinearity of their nonsynaptic (somatic) membrane. The model reproduces qualitatively the steady-state responses of an hyperpolarizing bipolar cell to the light spot and an annulus. It gives also the adaptational (with a light background) shift of the cone-bipolar cell transfer function. The model can be applied to depolarizing bipolar cells and to C-type horizontal cells.
在任何化学突触中，都存在由突触后神经元产生的电流引发的电反馈。我们认为，在视网膜内陷突触的情况下，这种反馈可能相当有效。构建了一个二元突触（视锥细胞 - 水平细胞 - 双极细胞）模型，其中视锥细胞和双极细胞之间的传递函数由水平细胞的突触电流调制。这种调制源于视锥细胞和水平细胞之间细胞间隙上电位降的变化。该模型考虑了水平细胞之间的电耦合以及它们非突触（体细胞）膜的非线性。该模型定性地再现了超极化双极细胞对光点和环形光斑的稳态反应。它还给出了视锥细胞 - 双极细胞传递函数的适应性（在亮背景下）偏移。该模型可应用于去极化双极细胞和C型水平细胞。
