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妊娠期抗抑郁药的使用:我们是否更接近共识?

Antidepressant use in pregnancy: are we closer to consensus?

机构信息

Department of Personality, Evaluation and Psychological Treatments, Faculty of Psychology, National University of Distance Education (UNED), 10, Juan del Rosal, 28040, Madrid, Spain.

出版信息

Arch Womens Ment Health. 2019 Apr;22(2):189-197. doi: 10.1007/s00737-018-0906-2. Epub 2018 Aug 20.

DOI:10.1007/s00737-018-0906-2
PMID:30128847
Abstract

We specify and summarize significant data from recent large studies in a tool with which to aim at consensus on the question of whether and how serotonin-reuptake antidepressants should be used in pregnancy, on the basis that concern for the mental health of the mother should not vie for primacy with concern for the short-, medium-, and long-term health of the child, but must be best served together. Side effects are small but significant over the majority of 11 categories, perinatal and into adolescence. In clinical practice, alternatives for serotonin-reuptake medication in pregnancy should be more actively pursued.

摘要

我们在一个工具中指定并总结了最近的大型研究中的重要数据,旨在就是否以及如何在怀孕期间使用 5-羟色胺再摄取抑制剂这一问题达成共识,因为对母亲心理健康的关注不应与对儿童短期、中期和长期健康的关注相竞争,而必须共同得到最好的服务。在 11 个类别中的大多数中,包括围产期和青春期,副作用很小但很显著。在临床实践中,应该更积极地寻找 5-羟色胺再摄取抑制剂的替代药物。

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Antidepressant use in pregnancy: are we closer to consensus?妊娠期抗抑郁药的使用:我们是否更接近共识?
Arch Womens Ment Health. 2019 Apr;22(2):189-197. doi: 10.1007/s00737-018-0906-2. Epub 2018 Aug 20.
2
[Use of antidepressants during pregnancy].[孕期使用抗抑郁药]
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SSRI use during pregnancy.孕期使用选择性5-羟色胺再摄取抑制剂
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The use of antidepressants in pregnancy: focus on maternal risks.孕期使用抗抑郁药:关注母亲风险。
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Selective Serotonin Reuptake Inhibitors as First-Line Antidepressant Therapy for Perinatal Depression.选择性5-羟色胺再摄取抑制剂作为围产期抑郁症的一线抗抑郁治疗方法
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Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort.孕期抑郁症患者队列中孕期使用抗抑郁药与严重先天性畸形风险:魁北克孕期队列的最新分析
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A rock and a hard place: The selective serotonin reuptake inhibitor dilemmas in addressing perinatal mood and anxiety disorders.进退两难:选择性5-羟色胺再摄取抑制剂在治疗围产期情绪和焦虑障碍方面的困境
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The safety of antidepressant use in pregnancy.孕期使用抗抑郁药的安全性。
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The effect of perinatal exposures on the infant: antidepressants and depression.围产期暴露对婴儿的影响:抗抑郁药与抑郁症。
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Pregnancy and postpartum antidepressant use moderates the effects of sleep on depression.孕期及产后使用抗抑郁药物会缓和睡眠对抑郁症的影响。
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