Liu Mo-Nan, Zhang Meng-Meng, Li Jing-Ya, Li Jia, Fan Yao-Yue, Yue Jian-Min
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
b University of Chinese Academy of Science , Beijing 100049 , China.
J Asian Nat Prod Res. 2018 Oct;20(10):909-919. doi: 10.1080/10286020.2018.1484455. Epub 2018 Aug 21.
Six new ent-labdane-type diterpeniods (1‒6), along with one known compound, were identified from the twigs and leaves of Croton laevigatus. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 2 and 7 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC values of 4.11 and 8.33 μg/ml, respectively.
从光果巴豆的嫩枝和叶子中鉴定出6种新的对映-贝壳杉烷型二萜（1-6）以及一种已知化合物。通过广泛的光谱解析阐明了它们的结构。化合物2和7对蛋白酪氨酸磷酸酶1B（PTP1B）显示出抑制活性，IC值分别为4.11和8.33μg/ml。
