Naranjo Antonio, Ojeda-Bruno Soledad, Saavedra Aida, Molina Amparo, Negrín Miguel
a Rheumatology , Hospital Universitario de Gran Canaria Doctor Negrín. University of Las Palmas de Gran Canaria , Las Palmas de Gran Canaria , Spain.
b Department of Quantitative Methods , University of Las Palmas de Gran Canaria , Las Palmas de Gran Canaria , pain.
Expert Rev Pharmacoecon Outcomes Res. 2019 Feb;19(1):81-87. doi: 10.1080/14737167.2018.1513791. Epub 2018 Sep 6.
Fracture Liaison Service (FLS) model for secondary prevention of fractures has demonstrated its cost-effectiveness using decision models. We analyze the impact of a FLS on pharmaceutical expenditures for osteoporosis (OP) in real-world circumstances.
Expenditures on OP medications from January 2011 to January 2017 were compiled. Pharmaceutical expenditures in the southern area of Gran Canaria were used as a control group to measure the impact of implementing an FLS in the northern area. We estimated generalized least squares regressions with interrupted time-series analysis where two interventions were considered: March 2012 (implementation of the FLS) and March 2016 (incorporation of nursing staff for inpatients with hip fracture).
The northern area incurred greater expenditures for group I and II drugs. The difference in bisphosphonates expenditures between areas varied from 10.5% higher in the northern area pre-FLS to 11.2% post-FLS and 18.3% since March 2016. However, interrupted time series models do not find a significant impact of implementation of FLS on the pharmaceutical expenditures for either drug group.
The implantation of an FLS did not lead to an increase in pharmaceutical expenditures for OP over the 5-year period compared to the standard care provided for secondary fracture preventions.
骨折联络服务（FLS）模式用于骨折的二级预防，已通过决策模型证明了其成本效益。我们分析了骨折联络服务（FLS）在实际情况下对骨质疏松症（OP）药物支出的影响。
汇总了2011年1月至2017年1月期间骨质疏松症药物的支出。将大加那利岛南部地区的药物支出用作对照组，以衡量在北部地区实施骨折联络服务（FLS）的影响。我们使用中断时间序列分析估计了广义最小二乘回归，其中考虑了两项干预措施：2012年3月（实施骨折联络服务（FLS））和2016年3月（为髋部骨折住院患者增加护理人员）。
北部地区在I类和II类药物上的支出更高。各地区双膦酸盐支出的差异从骨折联络服务（FLS）实施前北部地区高出10.5%，到实施后高出11.2%，自2016年3月以来高出18.3%。然而，中断时间序列模型未发现骨折联络服务（FLS）的实施对任何一个药物组的药物支出有显著影响。
与为骨折二级预防提供的标准护理相比，在5年期间实施骨折联络服务（FLS）并未导致骨质疏松症药物支出增加。
