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本文引用的文献

1
Development and validation of a stability-indicating RP-HPLC method for estimation of atazanavir sulfate in bulk.用于原料药硫酸阿扎那韦含量测定的稳定性指示反相高效液相色谱法的建立与验证
J Pharm Anal. 2017 Apr;7(2):134-140. doi: 10.1016/j.jpha.2013.12.002. Epub 2013 Dec 31.
2
mTOR Pathways in Cancer and Autophagy.癌症与自噬中的mTOR信号通路
Cancers (Basel). 2018 Jan 12;10(1):18. doi: 10.3390/cancers10010018.
3
Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains.系统性 HIV-1 感染会在人源化小鼠大脑中产生独特的神经胶质细胞特征。
Dis Model Mech. 2017 Dec 19;10(12):1489-1502. doi: 10.1242/dmm.031773.
4
Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles.制备具有改良抗逆转录病毒特征的纳米结构卡博特韦前药。
Biomaterials. 2018 Jan;151:53-65. doi: 10.1016/j.biomaterials.2017.10.023. Epub 2017 Oct 15.
5
Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry.使用多光谱成像流式细胞术通过测量LC3、p62和LAMP1共定位来评估自噬通量。
J Vis Exp. 2017 Jul 21(125):55637. doi: 10.3791/55637.
6
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.HIV-1相关神经认知障碍：流行病学、发病机制、诊断与治疗。
J Neurol. 2017 Aug;264(8):1715-1727. doi: 10.1007/s00415-017-8503-2. Epub 2017 May 31.
7
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications.介孔二氧化硅纳米颗粒作为核酸细胞内递送及后续治疗应用的载体
Molecules. 2017 May 11;22(5):782. doi: 10.3390/molecules22050782.
8
A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy.在用长效抗逆转录病毒疗法治疗后的人源化小鼠中，成熟巨噬细胞是主要的HIV-1细胞储存库。
Retrovirology. 2017 Mar 9;14(1):17. doi: 10.1186/s12977-017-0344-7.
9
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.评估GTM-1、雷帕霉素和卡马西平对自噬及阿尔茨海默病的疗效。
Med Sci Monit. 2017 Feb 14;23:801-808. doi: 10.12659/msm.898679.
10
Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs.自噬促进巨噬细胞对缓释纳米制剂抗逆转录病毒药物的储存。
J Clin Invest. 2017 Mar 1;127(3):857-873. doi: 10.1172/JCI90025. Epub 2017 Jan 30.

调控细胞自噬实现控释抗逆转录病毒药物。

Modulating cellular autophagy for controlled antiretroviral drug release.

机构信息

Department of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE 68198, USA.

Department of Neurology, University of Rochester Medical Centre, Rochester, NY 14618, USA.

出版信息

Nanomedicine (Lond). 2018 Sep;13(17):2139-2154. doi: 10.2217/nnm-2018-0224. Epub 2018 Aug 21.

DOI:10.2217/nnm-2018-0224
PMID:30129397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6219451/
Abstract

AIM

Pharmacologic agents that affect autophagy were tested for their abilities to enhance macrophage nanoformulated antiretroviral drug (ARV) depots and its slow release.

METHODS

These agents included URMC-099, rapamycin, metformin, desmethylclomipramine, 2-hydroxy-β-cyclodextrin (HBC) and clonidine. Each was administered with nanoformulated atazanavir (ATV) nanoparticles to human monocyte-derived macrophages. ARV retention, antiretroviral activity and nanocrystal autophagosomal formation were evaluated.

RESULTS

URMC-099, HBC and clonidine retained ATV. HBC, URMC-099 and rapamycin improved intracellular ATV retention. URMC-099 proved superior among the group in affecting antiretroviral activities.

CONCLUSION

Autophagy inducing agents, notably URMC-099, facilitate nanoformulated ARV depots and lead to sustained release and improved antiretroviral responses. As such, they may be considered for development as part of long acting antiretroviral treatment regimens.

摘要

目的

研究影响自噬的药物是否具有增强巨噬细胞纳米载药抗逆转录病毒药物（ARV）库及其缓慢释放的能力。

方法

这些药物包括 URMC-099、雷帕霉素、二甲双胍、去甲氯米帕明、2-羟-β-环糊精（HBC）和可乐定。将每种药物与纳米载药阿扎那韦（ATV）纳米颗粒一起用于人单核细胞衍生的巨噬细胞。评估 ARV 保留、抗逆转录病毒活性和纳米晶体自噬体形成。

结果

URMC-099、HBC 和可乐定保留 ATV。HBC、URMC-099 和雷帕霉素改善了细胞内 ATV 的保留。URMC-099 在影响抗逆转录病毒活性方面优于其他组。

结论

自噬诱导剂，特别是 URMC-099，可促进纳米载药 ARV 库的形成，并导致持续释放和改善抗逆转录病毒反应。因此，它们可能被考虑作为长效抗逆转录病毒治疗方案的一部分进行开发。