1 Department of Biology, Worcester State College, Worcester, Massachusetts.
2 Department of Medicine, University of Massachusetts Medical School , Worcester, Massachusetts.
Hum Gene Ther. 2018 Sep;29(9):966-970. doi: 10.1089/hum.2018.066. Epub 2018 Aug 21.
DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.
DNA 疫苗是 20 世纪 90 年代初由几个研究小组开创的。本文介绍了其中一个小组在研究鸡逆转录病毒载体方面的工作，这些工作为 DNA 疫苗的发现和早期发展做出了贡献。尽管最初这些发现受到了怀疑，但这里呈现的工作与其他研究结合起来，创立了一种新的疫苗接种方法：直接接种编码目标抗原的纯化 DNA。
