Castillo J A, Picado C
Allergol Immunopathol (Madr). 1986 Mar-Apr;14(2):133-7.
Tolerance to aspirin was induced in thirteen asthmatics with aspirin-intolerance. Starting with the lowest aspirin doses eliciting bronchospasm, the dose of aspirin was progressively increased up to a 1000 mg tolerance level. Tolerance was rapidly achieved when initial threshold doses were greater than 150 mg. Daily aspirin administration led to prolonged tolerance. Desensitization to aspirin may be useful in aspirin-sensitive asthmatic patients who require antiinflammatory or antithrombotic treatment.
对13名阿司匹林不耐受的哮喘患者诱导产生了对阿司匹林的耐受性。从引发支气管痉挛的最低阿司匹林剂量开始，阿司匹林剂量逐渐增加至1000毫克耐受水平。当初始阈值剂量大于150毫克时，能迅速达到耐受性。每日服用阿司匹林可导致耐受性延长。对于需要抗炎或抗血栓治疗的阿司匹林敏感型哮喘患者，阿司匹林脱敏可能有用。
