Rothe T, Achermann R, Hug J, Karrer W
Luzerner Höhenklinik, Montana, Switzerland.
Int Arch Allergy Immunol. 1996 Mar;109(3):298-300. doi: 10.1159/000237254.
Aspirin desensitization is a valuable treatment for aspirin-sensitive sinusitis. We present a case where long-term desensitization failed. While undergoing desensitization, our patient had prolonged severe asthmatic reactions and therefore received high intravenous doses of prednisone. We hypothesize that high steroid doses administered at the time of desensitization may have raised the threshold of intolerance to a point where the administered aspirin doses were tolerated. Consequently, symptoms of intolerance subsided during the procedure. Subsequent tapering down of the daily prednisone dose caused a re-emergence of the symptoms of intolerance, apparently due to a decrease in the intolerance threshold.
阿司匹林脱敏是治疗阿司匹林敏感型鼻窦炎的一种有效方法。我们报告一例长期脱敏失败的病例。在脱敏过程中，我们的患者出现了长时间的严重哮喘反应，因此接受了大剂量静脉注射泼尼松。我们推测，脱敏时给予的高剂量类固醇可能提高了不耐受阈值，使所给予的阿司匹林剂量能够被耐受。因此，不耐受症状在脱敏过程中消失。随后每日泼尼松剂量逐渐减少，不耐受症状再次出现，显然是由于不耐受阈值降低所致。
