School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, China; Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
J Colloid Interface Sci. 2018 Dec 15;532:767-773. doi: 10.1016/j.jcis.2018.07.099. Epub 2018 Jul 24.
Fluorescent carbon nanoparticles (FCNs) have gradually become the most promising alternative candidates to other traditional fluorescent nanomaterials for biological applications on account of their excellent fluorescence property and remarkable biocompatibility. Although many methods have reported on the preparation of FCNs, to date, no studies have reported the preparation of polymers of functionalized FCNs. A high-efficiency method was developed in this work to synthesize high-quality poly(ethylene oxide) (PEG)-functionalized FCNs from cigarette ash and thiol group-containing PEG via a facile one-pot ultrasonic irradiation treatment. A series of characterization techniques demonstrated the uniform nanoscale size, good fluorescence stability, high water dispersibility and remarkable biocompatibility of the generated FCNs. Furthermore, cell imaging was easily achieved at high resolution using the synthetic FCNs as probes, which validates their potential for bioimaging applications. In summary, an efficient one-pot strategy is reported for the first time on the preparation of PEG-functionalized FCNs with the assistance of ultrasonic irradiation. This method should be of great research interest for the fabrication of other polymer-functionalized FCNs with designable properties and functions.
荧光碳纳米粒子（FCNs）由于其优异的荧光性能和显著的生物相容性，逐渐成为生物应用中其他传统荧光纳米材料最有前途的替代品。尽管已经有许多方法报道了 FCNs 的制备，但迄今为止，尚无研究报道功能性 FCNs 的聚合物的制备。本工作开发了一种高效的方法，通过简便的一锅超声辐照处理，从烟灰和含巯基的聚乙二醇（PEG）制备高质量的聚（氧化乙烯）（PEG）功能化 FCNs。一系列的表征技术证明了所生成的 FCNs 的均匀纳米级尺寸、良好的荧光稳定性、高水分散性和显著的生物相容性。此外，使用合成的 FCNs 作为探针很容易实现高分辨率的细胞成像，验证了它们在生物成像应用中的潜力。总之，本文首次报道了在超声辐射辅助下，通过一锅法制备 PEG 功能化 FCNs 的有效策略。这种方法对于制备具有设计性能和功能的其他聚合物功能化 FCNs 应该具有重要的研究意义。
