Bernabe-Ortiz Antonio, Perel Pablo, Miranda Juan Jaime, Smeeth Liam
CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima 18, Peru; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Prim Care Diabetes. 2018 Dec;12(6):517-525. doi: 10.1016/j.pcd.2018.07.015. Epub 2018 Aug 18.
To assess the diagnostic accuracy of the Finnish Diabetes Risk Score (FINDRISC) for undiagnosed T2DM and to compare its performance with the Latin-American FINDRISC (LA-FINDRISC) and the Peruvian Risk Score.
A population-based study was conducted. T2DM and undiagnosed T2DM were defined using oral glucose tolerance test (OGTT). Risk scores assessed were FINDRISC, LA-FINDRISC and Peruvian Risk Score. Diagnostic accuracy of risk scores was estimated using the c-statistic and the area under the ROC curve (aROC). A simplified version of FINDRISC was also derived.
Data from 1609 individuals, mean age 48.2 (SD: 10.6), 810 (50.3%) women, were collected. A total of 176 (11.0%; 95%CI: 9.4%-12.5%) were classified as having T2DM, and 71 (4.7%; 95%CI: 3.7%-5.8%) were classified as having undiagnosed T2DM. Diagnostic accuracy of the FINDRISC (aROC=0.69), LA-FINDRISC (aROC=0.68), and Peruvian Risk Score (aROC=0.64) was similar (p=0.15). The simplified FINDRISC, with 4 variables, had a slightly better performance (aROC=0.71) than the other scores.
The performance of FINDRISC, LA-FINDRISC and Peruvian Risk Score for undiagnosed T2DM was similar. A simplified FINDRISC can perform as well or better for undiagnosed T2DM. The FINDRISC may be useful to detect cases of undiagnosed T2DM in resource-constrained settings.
评估芬兰糖尿病风险评分（FINDRISC）对未诊断出的2型糖尿病（T2DM）的诊断准确性，并将其性能与拉丁美洲FINDRISC（LA - FINDRISC）和秘鲁风险评分进行比较。
开展了一项基于人群的研究。使用口服葡萄糖耐量试验（OGTT）定义T2DM和未诊断出的T2DM。评估的风险评分包括FINDRISC、LA - FINDRISC和秘鲁风险评分。使用c统计量和ROC曲线下面积（aROC）估计风险评分的诊断准确性。还推导了FINDRISC的简化版本。
收集了1609名个体的数据，平均年龄48.2（标准差：10.6），810名（50.3%）为女性。共有176名（11.0%；95%置信区间：9.4% - 12.5%）被归类为患有T2DM，71名（4.7%；95%置信区间：3.7% - 5.8%）被归类为患有未诊断出的T2DM。FINDRISC（aROC = 0.69）、LA - FINDRISC（aROC = 0.68）和秘鲁风险评分（aROC = 0.64）的诊断准确性相似（p = 0.15）。具有4个变量的简化FINDRISC的性能（aROC = 0.71）比其他评分略好。
FINDRISC、LA - FINDRISC和秘鲁风险评分对未诊断出的T2DM的性能相似。简化的FINDRISC对未诊断出的T2DM的表现可能同样好或更好。FINDRISC可能有助于在资源有限的环境中检测未诊断出的T2DM病例。
