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芬兰糖尿病风险评分在印度尼西亚人群中用于检测未诊断糖尿病和糖调节受损的翻译和性能。

Translation and performance of the Finnish Diabetes Risk Score for detecting undiagnosed diabetes and dysglycaemia in the Indonesian population.

机构信息

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Institute of Science in Healthy Ageing & healthcaRE (SHARE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

PLoS One. 2022 Jul 21;17(7):e0269853. doi: 10.1371/journal.pone.0269853. eCollection 2022.

Abstract

A diabetes risk score cannot directly be translated and applied in different populations, and its performance should be evaluated in the target population. This study aimed to translate the Finnish Diabetes Risk Score (FINDRISC) instrument and compare its performance with the modified version for detecting undiagnosed type 2 diabetes mellitus (T2DM) and dysglycaemia among the Indonesian adult population. Forward and backward translations were performed and followed by cultural adaptation. In total, 1,403 participants were recruited. The FINDRISC-Bahasa Indonesia (FINDRISC-BI) was scored according to the original FINDRISC instrument, while a Modified FINDRISC-BI was analyzed using a specific body mass index and waist circumference classification for Indonesians. The area under the receiver operating characteristic curve, sensitivity, specificity, and the optimal cut-offs of both instruments were estimated. The area under the receiver operating characteristic curve for detecting undiagnosed T2DM was 0.73 (0.67-0.78) for the FINDRISC-BI with an optimal cut-off score of ≥9 (sensitivity = 63.0%; specificity = 67.3%) and 0.72 (0.67-0.78) for the Modified FINDRISC-BI with an optimal cut-off score of ≥11 (sensitivity = 59.8%; specificity = 74.9%). The area under the receiver operating characteristic curve for detecting dysglycaemia was 0.72 (0.69-0.75) for the FINDRISC-BI instrument with an optimal cut-off score of ≥8 (sensitivity = 66.4%; specificity = 67.0%), and 0.72 (0.69-0.75) for the Modified FINDRISC-BI instrument with an optimal cut-off score ≥9 (sensitivity = 63.8%; specificity = 67.6%). The Indonesian version of the FINDRISC instrument has acceptable diagnostic accuracy for screening people with undiagnosed T2DM or dysglycaemia in Indonesia. Modifying the body mass index and waist circumference classifications in the Modified FINDRISC-BI results in a similar diagnostic accuracy; however, the Modified FINDRISC-BI has a higher optimal cut-off point than the FINDRISC-BI. People with an above optimal cut-off score are suggested to take a further blood glucose test.

摘要

糖尿病风险评分不能直接在不同人群中进行翻译和应用,其性能应在目标人群中进行评估。本研究旨在翻译芬兰糖尿病风险评分(FINDRISC)工具,并比较其在印度尼西亚成年人群中检测未诊断 2 型糖尿病(T2DM)和糖调节受损的性能。进行了正向和反向翻译,随后进行了文化适应。总共招募了 1403 名参与者。根据原始的 FINDRISC 工具对 FINDRISC-Bahasa 印度尼西亚(FINDRISC-BI)进行评分,而使用特定的体重指数和腰围分类对印度尼西亚人进行分析的改良 FINDRISC-BI。估计了两种仪器的受试者工作特征曲线下面积、灵敏度、特异性和最佳截断值。用于检测未诊断的 T2DM 的受试者工作特征曲线下面积为 FINDRISC-BI 的 0.73(0.67-0.78),最佳截断评分≥9(灵敏度=63.0%;特异性=67.3%)和改良 FINDRISC-BI 的 0.72(0.67-0.78),最佳截断评分≥11(灵敏度=59.8%;特异性=74.9%)。用于检测糖调节受损的受试者工作特征曲线下面积为 FINDRISC-BI 仪器的 0.72(0.69-0.75),最佳截断评分≥8(灵敏度=66.4%;特异性=67.0%),改良 FINDRISC-BI 仪器的 0.72(0.69-0.75),最佳截断评分≥9(灵敏度=63.8%;特异性=67.6%)。FINDRISC 仪器的印度尼西亚版本对筛查印度尼西亚未诊断的 T2DM 或糖调节受损患者具有可接受的诊断准确性。修改改良 FINDRISC-BI 中的体重指数和腰围分类会导致相似的诊断准确性;然而,改良 FINDRISC-BI 的最佳截断值高于 FINDRISC-BI。建议截断值以上的人进行进一步的血糖检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/991a/9302803/4c4a10a0d698/pone.0269853.g001.jpg

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