Ambrona de Marcos Verónica, Bach Foradada Pilar, Alsedà Graells Miquel, Duque Jiménez Teresa, Delgado Roche Eduardo, Aguilar Ariza Rocío, Bravo Andrés Natalia, Godoy Pere
Instituto Catalán de la Salud (ICS) de Lleida. Lleida. España.
Servicio de Vigilancia Epidemiológica. Agencia de Salud Pública de Cataluña. Lleida. España.
Rev Esp Salud Publica. 2018 Aug 27;92:e201808057.
Compliance with the treatment of Latent Tuberculous Infection (ITL) is a determining factor in the control of tuberculosis. The objective of this study was to estimate the acceptance and compliance of the ITL treatment, and associated factors in contacts of patients with tuberculosis in Lleida.
Epidemiological analytical observational study, of a retrospective cohort follow-up, since the 1 January 2015 to 31 December 2016. The Participants were contacts of patients with tuberculosis in Lleida. Variables of the index case and independent and dependent variables (acceptance and compliance of the treatment) of contacts were studied through univariate and bivariate analysis. The strength of association was studied with odds ratio (OR) and confidence interval (IC) of 95% they were adjusted by a multivariate regression model.
69.1% of tuberculosis cases had a contact study, and 47.5% had at least one contact with prescription of preventive treatment. The treatment was accepted by 94.5% of contacts, and only 70.3% finalized this treatment. The completion was more frequent in patients who knew the meaning of latent tuberculosis infection treatment (ORa: 2.0; CI: 95% 1.0-4.1).
潜伏性结核感染（LTBI）治疗的依从性是控制结核病的一个决定性因素。本研究的目的是评估莱里达省结核病患者接触者对LTBI治疗的接受程度和依从性以及相关因素。
进行一项回顾性队列随访的流行病学分析观察性研究，时间跨度为2015年1月1日至2016年12月31日。参与者为莱里达省结核病患者的接触者。通过单变量和双变量分析研究索引病例的变量以及接触者的自变量和因变量（治疗的接受程度和依从性）。采用比值比（OR）和95%置信区间（CI）研究关联强度，并通过多变量回归模型进行调整。
69.1%的结核病病例进行了接触者研究，47.5%的病例至少有一名接触者接受了预防性治疗处方。94.5%的接触者接受了治疗，但只有70.3%的人完成了治疗。了解潜伏性结核感染治疗意义的患者完成治疗的情况更为常见（调整后比值比：2.0；95%置信区间：1.0 - 4.1）。
