Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, and the School of Chemistry and Chemical Engineering , Shandong University , Jinan , Shandong 250100 , China.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical Engineering , The University of Melbourne , Parkville , Victoria 3010 , Australia.
Langmuir. 2018 Sep 18;34(37):10817-10827. doi: 10.1021/acs.langmuir.8b02117. Epub 2018 Aug 22.
The assembly of particles composed solely or mainly of poly(ethylene glycol) (PEG) is an emerging area that is gaining increasing interest within bio-nano science. PEG, widely considered to be the "gold standard" among polymers for drug delivery, is providing a platform for exploring fundamental questions and phenomena at the interface between particle engineering and biomedicine. These include the targeting and stealth behaviors of synthetic nanomaterials in biological environments. In this feature article, we discuss recent work in the nanoengineering of PEG particles and explore how they are enabling improved targeting and stealth performance. Specific examples include PEG particles prepared through surface-initiated polymerization, mesoporous silica replication via postinfiltration, and particle assembly through metal-phenolic coordination. This particle class exhibits unique in vivo behavior (e.g., biodistribution and immune cell interactions) and has recently been explored for drug delivery applications.
仅由聚乙二醇（PEG）或主要由聚乙二醇组成的颗粒组装是生物纳米科学中一个日益受到关注的新兴领域。PEG 被广泛认为是药物输送用聚合物中的“金标准”，为探索颗粒工程与生物医学之间界面的基本问题和现象提供了一个平台。这些问题和现象包括在生物环境中合成纳米材料的靶向和隐身行为。在这篇专题文章中，我们讨论了 PEG 颗粒的纳米工程的最新进展，并探讨了它们如何提高靶向和隐身性能。具体示例包括通过表面引发聚合制备的 PEG 颗粒、通过后渗透法复制的介孔硅、以及通过金属-酚配位组装的颗粒。这类颗粒表现出独特的体内行为（例如，生物分布和免疫细胞相互作用），最近已被探索用于药物输送应用。
