Yang Shuang, Ding Feng, Gao Zhiliang, Guo Jianman, Cui Jiwei, Zhang Peiyu
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Polymers (Basel). 2020 May 14;12(5):1124. doi: 10.3390/polym12051124.
To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. The obtained capsules composed of 8-arm-PEG result in a lower cell association (2.2%) compared to those composed of linear PEG (7.3%) and, therefore, demonstrate the stealth property. The functionalization of cyclic peptides containing Arg-Gly-Asp (cRGD) on PEG capsules induce high cell targeting to U87 MG cells. A cell cytotoxicity assay demonstrates the biocompatibility of PEG capsules and high drug delivery efficacy of the targeted capsules. The reported capsules with the stealth and targeting property provide a potential platform for improved drug delivery.
为了减少非特异性相互作用并规避生物屏障，聚乙二醇（PEG）低污染材料最常用于药物纳米载体的修饰。在此，我们报告了通过线性PEG或8臂PEG的自由基聚合，使用乳液模板法制备用于靶向药物递送的PEG胶囊。阿霉素（DOX）可通过静电相互作用载入胶囊。与由线性PEG组成的胶囊（7.3%）相比，由8臂PEG组成的所得胶囊导致较低的细胞结合率（2.2%），因此表现出隐形特性。PEG胶囊上含精氨酸-甘氨酸-天冬氨酸（cRGD）的环肽功能化诱导对U87 MG细胞的高细胞靶向性。细胞毒性试验证明了PEG胶囊的生物相容性和靶向胶囊的高药物递送效率。所报道的具有隐形和靶向特性的胶囊为改善药物递送提供了一个潜在平台。
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