Iodine(III)-Mediated Electrochemical Trifluoroethoxylactonisation: Rational Reaction Optimisation and Prediction of Mediator Activity.

A new electrochemical iodine(III)-mediated cyclisation reaction for the synthesis of 4-(2,2,2-trifluoroethoxy)isochroman-1-ones is presented. Based on this reaction design of experiments and multivariate linear regression analysis were used to demonstrate their first application in an electrochemical reaction. The broad applicability of these reaction conditions could be shown by a range of substrates and an extensive compatibility test.