Ierace Maria K, Canfield Michael S, Peters-Kennedy Jeanine, Kane Curtis W
Animal Dermatology South LLC, 7741 Congress St, New Port Richey, FL, 34653, USA.
Department of Biomedical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Vet Dermatol. 2018 Oct;29(5):431-e142. doi: 10.1111/vde.12683. Epub 2018 Aug 21.
Squamous cell carcinoma (SCC) is the most commonly reported neoplasm of the nasal planum and treatment is focused on localized disease. Rostral maxillectomy and/or nasal planectomy are considered standard of care for excision of nasal planum SCC; however, the cosmetic outcome of these procedures can be deemed unacceptable by many pet owners.
The study aim was to evaluate the efficacy of combination carbon dioxide (CO ) laser surgery and cryosurgery as a palliative treatment modality in dogs with nasal SCCs.
Ten client-owned dogs with nasal SCC were included: seven neutered males, two spayed females and one intact male, with a median age of 12.5 years (range 9-15 years).
Tumour CO laser ablation was followed by cryosurgical ablation of the visible tumour, adjacent and subjacent tissue. Three rapid freeze-slow thaw cycles were performed.
Eight of 10 dogs were Labrador retrievers. The ages ranged from 9 to 14 years. Overall median survival time was 260 days with two dogs still alive at the time of writing.
Combined CO laser and cryosurgical ablation was practical, cost-effective and provided an excellent aesthetic outcome in dogs with SCCs restricted to the nasal septum, while providing acceptable palliation of local disease.
鳞状细胞癌（SCC）是鼻平面最常报道的肿瘤，治疗主要针对局限性疾病。上颌骨前部切除术和/或鼻平面切除术被认为是切除鼻平面SCC的标准治疗方法；然而，许多宠物主人可能认为这些手术的美容效果不可接受。
本研究旨在评估二氧化碳（CO₂）激光手术和冷冻手术联合作为犬鼻SCC姑息治疗方式的疗效。
纳入10只患鼻SCC的客户拥有的犬：7只去势雄性犬、2只绝育雌性犬和1只未绝育雄性犬，中位年龄为12.5岁（范围9 - 15岁）。
先用CO₂激光消融肿瘤，然后对可见肿瘤、相邻和下方组织进行冷冻手术消融。进行三个快速冷冻 - 缓慢解冻循环。
10只犬中有8只为拉布拉多寻回犬。年龄范围为9至14岁。总体中位生存时间为260天，撰写本文时仍有2只犬存活。
CO₂激光和冷冻手术联合消融实用、经济有效，对于局限于鼻中隔的SCC犬能提供良好的美容效果，同时能对局部疾病提供可接受的姑息治疗。
