Anjos of Assis Veterinary Medicine Centre (CMVAA), Barreiro, Portugal.
Department of Clinics, Surgery, Faculty of Veterinary Medicine University of Lisbon (FMV_ULisboa), 1300, Lisbon, Portugal.
Lasers Med Sci. 2024 Apr 25;39(1):114. doi: 10.1007/s10103-024-04059-2.
Nasal mucosa tumors are an uncommon process and very dificult to work on with surgery. Radiotherapy associated or not with chemotherapy is the standard method to treat the disease. However, its access it is in the majority of the case not possible, making the surgery the best choice to try to achieve the patient's control. The anatomy of the region makes the complete surgical resection very difficult to achieve using the common and conventional blade scalpel surgery. The study features the advantages of using a CO laser to perform nasal mucosa carcinoma surgery in 6 dogs (N = 6). For the work we used an Aesculigth CO surgical laser model -Vetscalpel®, with the settings of 12Watts in a Superpulse mode, and a 0.25-0.4 mm focus to dissect the nasal mucosa, and a 1.5 mm focus for vaporization of the area. All the masses were histopathologically characterized as squamous cells carcinoma. The CO surgical laser allow us to work in a bloodless region promoting a more accurate dissection of the nasal mucosa sparing therefore the underlying and adjacent tissues and being less invasive. Also, it was possible to do the vaporization of the entire surgical area interviened. None of the patients presented relapse of clinical signs. Only 2 individuals were alive at the end of the study, presenting a survival rate of 420 and 514 days, which is in the same line of literature results of the treatment with radiotherapy combined with chemotherapy wich shows a median of 474-580 days. The study demonstrates successful outcomes with CO laser surgery in treating nasal mucosa SCC in dogs, with patients experiencing improved survival rates compared to traditional treatment methods. This highlights the efficacy and potential of CO laser surgery as a valuable tool in managing aggressive nasal tumors in veterinary oncology.
鼻腔黏膜肿瘤是一种罕见的疾病，手术治疗非常困难。放射治疗联合或不联合化疗是治疗该疾病的标准方法。然而，由于大多数情况下无法进行放射治疗，手术成为了尝试控制疾病的最佳选择。该区域的解剖结构使得使用普通和常规刀片手术刀进行完全手术切除非常困难。
本研究的特点是在 6 只狗（N=6）中使用 CO 激光进行鼻腔黏膜癌手术的优势。我们使用的是 Aesculigth CO 手术激光模型-Vetscalpel®，设置为 12 瓦特的 Superpulse 模式，0.25-0.4 毫米的焦点用于解剖鼻腔黏膜，1.5 毫米的焦点用于汽化该区域。所有的肿块均经组织病理学特征为鳞状细胞癌。CO 手术激光使我们能够在无血区域进行操作，从而更准确地解剖鼻腔黏膜，避免了对下面和相邻组织的损伤，减少了侵袭性。此外，还可以对整个手术区域进行汽化处理。所有患者均未出现临床症状复发。研究结束时，只有 2 只个体存活，存活率分别为 420 天和 514 天，与放射治疗联合化疗的文献结果一致，中位存活时间为 474-580 天。该研究表明，CO 激光手术治疗犬鼻腔黏膜 SCC 取得了成功的结果，与传统治疗方法相比，患者的生存率有所提高。这突显了 CO 激光手术在兽医肿瘤学中作为治疗侵袭性鼻腔肿瘤的有效工具的疗效和潜力。
