p53 肿瘤抑制因子与铁稳态。
p53 tumor suppressor and iron homeostasis.
机构信息
Comparative Oncology Laboratory, School of Veterinary Medicine and Medicine, University of California at Davis, CA, USA.
出版信息
FEBS J. 2019 Feb;286(4):620-629. doi: 10.1111/febs.14638. Epub 2018 Sep 4.
Abstract
Iron is an essential nutrient for all living organisms and plays a vital role in many fundamental biochemical processes, such as oxygen transport, energy metabolism, and DNA synthesis. Due to its capability to produce free radicals, iron has deleterious effects and thus, its level needs to be tightly controlled in the body. Deregulation of iron metabolism is known to cause diseases, including anemia by iron deficiency and hereditary hemochromatosis by iron overload. Interestingly, dysregulated iron metabolism occurs frequently in tumor cells and contributes to tumorigenesis. In this review, we will discuss the role of p53 tumor suppressor in iron homeostasis.
摘要
铁是所有生物的必需营养素，在许多基本的生化过程中发挥着重要作用，如氧气运输、能量代谢和 DNA 合成。由于铁能够产生自由基，因此具有有害作用，因此其水平需要在体内得到严格控制。铁代谢失调已知会导致疾病，包括缺铁性贫血和铁过载引起的遗传性血色素沉着症。有趣的是，铁代谢失调在肿瘤细胞中经常发生，并促进肿瘤发生。在这篇综述中，我们将讨论 p53 肿瘤抑制因子在铁平衡中的作用。
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本文引用的文献
1
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Adv Mater. 2018 Mar;30(12):e1704007. doi: 10.1002/adma.201704007. Epub 2018 Jan 22.
2
p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells.p53 抑制癌细胞代谢应激诱导的铁死亡。
Cell Rep. 2018 Jan 16;22(3):569-575. doi: 10.1016/j.celrep.2017.12.077.
3
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