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以伞房状梅毒疹表现的二期梅毒:病例报告及文献复习

Secondary syphilis presenting as a corymbiform syphilide: case report and review.

作者信息

Eyer-Silva Walter de Araujo, Souza Viviane Primo Basílio de, Silva Guilherme Almeida Rosa da, Brasil Fernando Vieira, Portela Alessandra Dos Santos, Carvalho Ricardo de Souza, Neves-Motta Rogerio, Martins Carlos José

机构信息

Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 2018 Aug 20;60:e40. doi: 10.1590/S1678-9946201860040.

DOI:10.1590/S1678-9946201860040
PMID:30133600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6103325/
Abstract

It is essential that healthcare providers are familiar with the full spectrum of clinical presentations of syphilis. A rare manifestation of secondary syphilis is the corymbiform (or corymbose) arrangement, in which a central greater papule is surrounded by smaller satellite lesions. Very few reports of corymbiform syphilis are available in current biomedical databases. We present the case of a 28 year-old HIV-infected male patient on regular, successful antiretroviral therapy who developed an asymptomatic corymbiform maculopapular lesion in the medial aspect of the right thigh. There were also a few brownish macular lesions on the left sole. New serological tests for syphilis (which had been negative in the past) were reactive. The coymbiform lesion slowly regressed and the non-treponemal test reverted to negative after benzathine penicillin G treatment. A review of the literature is provided. This is the first report of corymbiform syphilis in an HIV-infected patient.

摘要

医疗保健提供者必须熟悉梅毒的全谱临床表现。二期梅毒的一种罕见表现是伞房状(或伞房样)排列,即中央有一个较大的丘疹,周围环绕着较小的卫星状损害。目前的生物医学数据库中关于伞房状梅毒的报道极少。我们报告一例28岁感染HIV的男性患者,该患者正在接受规律且成功的抗逆转录病毒治疗,其右大腿内侧出现了一个无症状的伞房状斑丘疹损害。左足底也有一些褐色斑疹。新的梅毒血清学检测(过去为阴性)呈阳性反应。经苄星青霉素G治疗后,伞房状损害逐渐消退,非梅毒螺旋体试验转为阴性。本文提供了文献综述。这是首例关于感染HIV患者出现伞房状梅毒的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a42/6103325/503c0a24f85d/1678-9946-rimtsp-60-S1678-9946201860040-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a42/6103325/b24d63ed3640/1678-9946-rimtsp-60-S1678-9946201860040-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a42/6103325/503c0a24f85d/1678-9946-rimtsp-60-S1678-9946201860040-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a42/6103325/b24d63ed3640/1678-9946-rimtsp-60-S1678-9946201860040-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a42/6103325/503c0a24f85d/1678-9946-rimtsp-60-S1678-9946201860040-gf02.jpg

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本文引用的文献

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Corymbiform syphilis associated with three other sexually transmitted infections.花椰菜样梅毒合并其他三种性传播感染。
An Bras Dermatol. 2018 Jan-Feb;93(1):129-132. doi: 10.1590/abd1806-4841.20186850.
2
Secondary syphilis presenting as leucoderma syphiliticum: case report and review.表现为梅毒性白斑的二期梅毒:病例报告及文献复习
Rev Inst Med Trop Sao Paulo. 2017 Nov 6;59:e74. doi: 10.1590/S1678-9946201759074.
3
Corymbiform Lesions in a Young Healthy Man.一名年轻健康男性身上的伞房状病变
JAMA Dermatol. 2017 Dec 1;153(12):1317-1318. doi: 10.1001/jamadermatol.2017.2768.
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Secondary Syphilis Presenting as Glossodynia, , and a Split Papule at the Oral Commissure: Case Report and Review.以舌痛、[此处原文缺失部分内容]及口角分裂丘疹为表现的二期梅毒:病例报告及文献复习
Case Rep Med. 2017;2017:1980798. doi: 10.1155/2017/1980798. Epub 2017 Jul 12.
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Am J Trop Med Hyg. 2017 Feb 8;96(2):261-262. doi: 10.4269/ajtmh.16-0386.
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Malignant syphilis in an AIDS patient.一名艾滋病患者的恶性梅毒。
Infection. 2015 Apr;43(2):231-6. doi: 10.1007/s15010-014-0698-x. Epub 2014 Nov 19.
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The cutaneous manifestations of syphilis.梅毒的皮肤表现。
Can Med Assoc J. 1918 May;8(5):417-23.
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Small Follicular Syphilide of the Corymbose Type.伞房状小滤泡性梅毒疹
Proc R Soc Med. 1910;3(Dermatol Sect):1. doi: 10.1177/003591571000300302.
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Unusual cutaneous features of syphilis in patients positive for human immunodeficiency virus.艾滋病病毒阳性患者梅毒的不典型皮肤表现。
Clin Exp Dermatol. 2010 Mar;35(2):169-72. doi: 10.1111/j.1365-2230.2009.03257.x. Epub 2009 May 21.
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Syphilis: uncommon presentations in adults.梅毒:成人中的不常见表现。
Clin Dermatol. 2005 Nov-Dec;23(6):555-64. doi: 10.1016/j.clindermatol.2005.01.015.