从糖尿病患者中分离出的念珠菌属的体外抗真菌药敏性
In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients.
作者信息
Hedayati Mohammad Taghi, Tavakoli Mahin, Zakavi Fateme, Shokohi Tahereh, Mofarrah Ramin, Ansari Saham, Armaki Mojtaba Taghizadeh
机构信息
Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Rev Soc Bras Med Trop. 2018 Jul-Aug;51(4):542-545. doi: 10.1590/0037-8682-0332-2017.
INTRODUCTION
This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents.
METHODS
Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI).
RESULTS
Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates.
CONCLUSIONS
Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.
引言
本研究旨在评估从糖尿病患者中分离出的不同念珠菌属对八种抗真菌药物的抗真菌药敏性。
方法
采用临床和实验室标准协会（CLSI）的M27 - A3方案，对111株念珠菌临床分离株进行了针对8种抗真菌药物的药敏试验。
结果
伏立康唑、兰诺康唑和卡泊芬净对所有白色念珠菌分离株显示出最高的体外活性。仅在白色念珠菌分离株中观察到对所测试抗真菌药物的耐药性。
结论
我们的研究结果表明，白色念珠菌中可观察到对两性霉素B、伊曲康唑、酮康唑、泊沙康唑和氟康唑的耐药性。
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