伊朗临床分离株的抗真菌耐药性：一项系统评价和荟萃分析。

Antifungal Resistance of Clinical Isolates in Iran: A Systematic Review and Meta-Analysis.

作者信息

Kermani Firoozeh, Taghizadeh-Armaki Mojtaba, Hosseini Seyed Abdollah, Amirrajab Nasrin, Javidnia Javad, Fami Zaghrami Mahmoud, Shokohi Tahereh

机构信息

Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Medical Parasitology and Mycology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

出版信息

Iran J Public Health. 2023 Feb;52(2):290-305. doi: 10.18502/ijph.v52i2.11874.

BACKGROUND

The present systematic review aimed to investigate the drug susceptibility patterns of Iranian clinical isolates to antifungal drugs (azoles, polyenes, and echinocandins).

METHODS

Six electronic databases including "PubMed," "Scopus," "Web of Science," "IranDoc", "SID", and "Magiran" were searched from May 2000 to June 2021. The susceptibility of 6322 strains from 19967 patients against 14 antifungal drugs was evaluated according to CLSI method.

RESULTS

The pooled prevalence of antifungal resistance ranged from 0% to 26%. The lowest resistance levels among azoles were observed in luliconazole with a frequency of 0% and voriconazole of 3.94%.

CONCLUSION

Due to the emergence of multi-drug resistant rational drug prescription based on the anti-fungal stewardship strategy and therapeutic drug monitoring is warranted.