Yan Feng, Yi Zhang, Hua Yang, Shen Ying, Li Ming, Ding Yuchuan, Chandra Ankush, Ji Xunming, Yue Wei
a Department of Neurosurgery, Xuanwu Hospital , Capital Medical University , Beijing , China.
b Drug Clinical Trial Institution , Tianjin Huanhu Hospital , Tianjin , China.
Neurol Res. 2018 Jun;40(6):466-472. doi: 10.1080/01616412.2018.1451266.
Objective There are limited studies exploring prognosis after intracerebral hemorrhage (ICH) in Chinese populations. Thus, we evaluated the risk factors and predictors of mortality and recurrent stroke in a large clinical cohort at a single institution. Methods We analysed consecutive cases of spontaneous ICH at admission to our hospital from September 2010 to December 2016. Independent predictors of mortality at one month and five year follow-up, as well as stroke recurrence were analysed. Results A total of 1187 cases were included (33.5% women). The one month case fatality rate was 12.5%, and the five year mortality rate was 22.2%. In the multivariate analysis, diabetes was an independent predictor of one month case fatality, and older age (≥65 years) was an independent predictor of five year mortality. Brain stem hemorrhage and intraventricular hemorrhage were independent predictors of both short- and long-term mortality. The overall recurrence rate was 32.5% among one month survivors. Conclusion Predictors of recurrent stroke were older females, hypertension, diabetes, and brain stem hemorrhage. These findings may help to determine specific treatment strategies and improve quality of health care for such patients.
在中国人群中，探索脑出血（ICH）后预后情况的研究有限。因此，我们评估了单机构大型临床队列中死亡及复发性卒中的危险因素和预测因素。方法：我们分析了2010年9月至2016年12月期间我院收治的自发性ICH连续病例。分析了1个月和5年随访时死亡以及卒中复发的独立预测因素。结果：共纳入1187例病例（女性占33.5%）。1个月病死率为12.5%，5年死亡率为22.2%。多变量分析中，糖尿病是1个月病死率的独立预测因素，年龄较大（≥65岁）是5年死亡率的独立预测因素。脑干出血和脑室内出血是短期和长期死亡的独立预测因素。1个月幸存者中的总体复发率为32.5%。结论：复发性卒中的预测因素为老年女性、高血压、糖尿病和脑干出血。这些发现可能有助于确定此类患者的具体治疗策略并改善医疗保健质量。
