胰岛素依赖型糖尿病患者血小板上血管紧张素II受体数量减少。

Reduced number of angiotensin II receptors on platelets in insulin-dependent diabetes.

作者信息

Connell J M, Ding Y A, Fisher B M, Frier B M, Semple P F

出版信息

Clin Sci (Lond). 1986 Aug;71(2):217-20. doi: 10.1042/cs0710217.

Abstract

Angiotensin II receptors on platelets were studied in 13 patients with uncomplicated type I diabetes mellitus and in 15 age-matched normal subjects. Receptor density on cells from the diabetic patients was 15% lower than the normal subjects (5.2 +/- 0.8 SD sites/platelet in diabetic patients and 6.4 +/- 0.8 in normals, P less than 0.001), but there were no differences in receptor affinity as measured by Kd (4.9 +/- 1.5 X 10(-10) mol/l in diabetic patients and 5.4 +/- 1.4 X 10(-10) mol/l in normals). Plasma concentrations of renin and angiotensin II were similar in both groups. The reduced density of angiotensin II receptors on platelets from patients with insulin-dependent diabetes may reflect a generalized abnormality of angiotensin II receptor regulation.

摘要

对13例无并发症的I型糖尿病患者及15名年龄匹配的正常受试者的血小板上的血管紧张素II受体进行了研究。糖尿病患者细胞上的受体密度比正常受试者低15%（糖尿病患者为5.2±0.8标准差位点/血小板，正常人为6.4±0.8，P<0.001），但通过解离常数（Kd）测量的受体亲和力无差异（糖尿病患者为4.9±1.5×10⁻¹⁰mol/L，正常人为5.4±1.4×10⁻¹⁰mol/L）。两组的肾素和血管紧张素II血浆浓度相似。胰岛素依赖型糖尿病患者血小板上血管紧张素II受体密度降低可能反映了血管紧张素II受体调节的普遍异常。