Patocka Jiří, Franca Tanos C C, Wu Qinghua, Kuca Kamil
Department of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia Ceske Budejovice, 370 05 Ceske Budejovice, Czech Republic.
Biomedical Research Center, University Hospital Hradec Kralove, 500 03 Hradec Kralove, Czech Republic.
Toxics. 2018 Aug 22;6(3):51. doi: 10.3390/toxics6030051.
Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Despite this, human poisoning by this substance is unfortunately still very common. The largest number of poisonings are reported in China, but in the United States, dozens of poisonings still happen annually. TETS is one of the most hazardous pesticides and also a possible chemical warfare agent with no known antidote. In this article, we aim to summarize the biochemical and toxicological data of TETS and hope to cast some light on the toxicological risk to human health.
毒鼠强（TETS，四胺）是一种有毒的有机化合物，用作有效的灭鼠剂。然而，这种神经毒素不仅对啮齿动物有毒，对人类也会造成中毒。由于其对人类的高毒性，毒鼠强作为灭鼠剂的使用已被禁止，其生产也已停止。尽管如此，不幸的是，这种物质导致的人体中毒仍然非常普遍。中毒报告数量最多的是中国，但在美国，每年仍有数十起中毒事件发生。毒鼠强是最危险的农药之一，也是一种可能的化学战剂，目前尚无已知的解毒剂。在本文中，我们旨在总结毒鼠强的生化和毒理学数据，希望能对其对人类健康的毒理学风险有所了解。
