成年大鼠大脑中的骨形态发生蛋白7表达
BMP7 expression in the adult rat brain.
作者信息
Kusakawa Yuya, Mikawa Sumiko, Sato Kohji
机构信息
Department of Tissue & Organ Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan.
AICHI Medical College for Physical and Occupational Therapy, 519 Ichiba, Kiyosu, Aichi 452-0931, Japan.
出版信息
IBRO Rep. 2017 Jun 26;3:72-86. doi: 10.1016/j.ibror.2017.06.002. eCollection 2017 Dec.
Bone morphogenetic protein-7 (BMP7), a member of the transforming growth factor-β (TGF-β) superfamily, has various effects in many biological events. However, there is little information on BMP7 expression in the adult central nervous system (CNS). Therefore, we investigated BMP7 levels in the adult rat CNS using immunohistochemistry. Abundant BMP7 expression was seen in astrocytes throughout the CNS and strong BMP7 expression was also observed in neuropils of the gray matter. Furthermore, BMP7 expression was observed in several kinds of neurons, including oxytocin, dopaminergic and noradrenergic neurons. These data suggest that BMP7 is widely expressed throughout the adult CNS, and support the idea that BMP7 plays pivotal roles in the adult brain, as well as in the developing brain.
骨形态发生蛋白-7（BMP7）是转化生长因子-β（TGF-β）超家族的成员之一，在许多生物学事件中具有多种作用。然而，关于BMP7在成体中枢神经系统（CNS）中的表达情况知之甚少。因此，我们采用免疫组织化学方法研究了成年大鼠中枢神经系统中BMP7的水平。在整个中枢神经系统的星形胶质细胞中可见丰富的BMP7表达，在灰质的神经纤维网中也观察到强烈的BMP7表达。此外，在几种神经元中也观察到了BMP7的表达，包括催产素能神经元、多巴胺能神经元和去甲肾上腺素能神经元。这些数据表明，BMP7在整个成年中枢神经系统中广泛表达，并支持BMP7在成年大脑以及发育中的大脑中发挥关键作用的观点。
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