Hayashi Yutaro, Mikawa Sumiko, Masumoto Kazuma, Katou Fuminori, Sato Kohji
Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan; Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
J Chem Neuroanat. 2018 Apr;89:21-36. doi: 10.1016/j.jchemneu.2018.02.003. Epub 2018 Feb 12.
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), is a member of the transforming growth factor β (TGF-β) superfamily. Although GDF11 plays pivotal roles during development, including anterior/posterior patterning, formation of the kidney, stomach, spleen and endocrine pancreas, little information is available for GDF11 expression in the adult central nervous system (CNS). We, thus, investigated GDF11 expression in the adult rat CNS using immunohistochemistry. GDF11 was intensely expressed in most neurons and their axons. Furthermore, we found that astrocytes and ependymal cells also express GDF11 protein. These data indicate that GDF11 is widely expressed throughout the adult CNS, and its abundant expression in the adult brain strongly supports the idea that GDF11 plays important roles in the adult brain.
生长分化因子11（GDF11），也被称为骨形态发生蛋白11（BMP11），是转化生长因子β（TGF-β）超家族的成员。尽管GDF11在发育过程中发挥着关键作用，包括前后模式形成、肾脏、胃、脾脏和内分泌胰腺的形成，但关于GDF11在成体中枢神经系统（CNS）中的表达情况却知之甚少。因此，我们利用免疫组织化学方法研究了成年大鼠中枢神经系统中GDF11的表达。GDF11在大多数神经元及其轴突中强烈表达。此外，我们发现星形胶质细胞和室管膜细胞也表达GDF11蛋白。这些数据表明，GDF11在整个成体中枢神经系统中广泛表达，其在成体大脑中的丰富表达有力地支持了GDF11在成体大脑中发挥重要作用这一观点。
