心房利钠肽对人离体阻力动脉的作用。
The effect of atrial natriuretic peptide on human isolated resistance arteries.
作者信息
Hughes A D, Nielsen H, Sever P S
机构信息
Department of Clinical Pharmacology, St. Mary's Hospital Medical School, London.
出版信息
Br J Pharmacol. 1989 Aug;97(4):1027-30. doi: 10.1111/j.1476-5381.1989.tb12558.x.
Abstract
- The action of (1-28) alpha-human atrial natriuretic peptide (ANP) was studied on human isolated resistance arteries. 2. Renal, skeletal muscle, omental and subcutaneous resistance arteries were taken from tissue removed at surgery and isometric tension responses were measured with a myograph. 3. ANP (10(-9)-10(-6) M) relaxed precontracted segments of renal and skeletal muscle arteries in a concentration-dependent manner. ANP failed to relax isolated omental or subcutaneous arteries. 4. The effect of ANP on human isolated resistance arteries varies depending on the site of origin of the artery.
摘要
- 研究了（1 - 28）α-人心房利钠肽（ANP）对人离体阻力动脉的作用。2. 从手术切除的组织中获取肾、骨骼肌、网膜和皮下阻力动脉，并用肌动描记器测量等长张力反应。3. ANP（10⁻⁹ - 10⁻⁶ M）以浓度依赖性方式使肾和骨骼肌动脉的预收缩节段舒张。ANP未能使离体网膜或皮下动脉舒张。4. ANP对人离体阻力动脉的作用因动脉的起源部位而异。
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