Yoon Hyung, Marchese Austin D, Lautens Mark
Davenport Research Laboratories, Department of Chemistry , University of Toronto , Toronto , Ontario M5S 3H6 , Canada.
J Am Chem Soc. 2018 Sep 5;140(35):10950-10954. doi: 10.1021/jacs.8b06966. Epub 2018 Aug 23.
A novel nickel-catalyzed cycloisomerization reaction forming a new carbon-carbon bond while preserving the carbon-halogen bond has been developed. A cheap and readily available Ni-catalyst is employed to generate nitrogen containing heterocycles in good to excellent yields and the procedure is readily scalable. The more readily available aryl bromides were also cyclized with the addition of potassium iodide to generate the respective alkyl iodides. A rare dual ligand system employing a bisphosphine and bisphosphine monoxide was used to achieve enantioenriched products.
已开发出一种新型镍催化的环异构化反应，该反应在保留碳 - 卤键的同时形成新的碳 - 碳键。使用一种廉价且易于获得的镍催化剂以良好至优异的产率生成含氮杂环，并且该方法易于扩大规模。通过添加碘化钾，更易于获得的芳基溴化物也能环化生成相应的烷基碘化物。采用双膦和单膦双氧化物的罕见双配体体系来获得对映体富集产物。
