Ripples in scalp EEGs of children: co-occurrence with sleep-specific transients and occurrence across sleep stages.

STUDY OBJECTIVES

A dialogue between hippocampal ripples (80-250 Hz) and neocortical sleep-specific transients is important for memory consolidation. Physiological neocortical ripples can be recognized in scalp EEGs of children. We investigated how often scalp-EEG recorded ripples co-occur with different types of sleep-specific transients, the distribution and spatial extent of ripples with and without co-occurring sleep-specific transients, and the occurrence of ripples across sleep stages.

METHODS

We marked ripples in daytime sleep-EEGs of 19 children and determined for each ripple if it co-occurred with a sleep-specific transient. We compared the distribution of ripples without co-occurring sleep-specific transients to the distribution of all ripples. We estimated the spatial extent of simultaneously occurring ripples by counting how many EEG regions they comprised. We compared ripple rate per sleep stage using Friedman's analysis of variance and Wilcoxon signed-rank test.

RESULTS

74.4 % of ripples co-occurred with sleep-specific transients: 27.8 % with vertex waves, 14.7 % with hypnagogic hypersynchrony, 13.7 % with slow waves, 12.2 % with spindles, and 6.0 % with K-complexes. Ripples without co-occurring sleep-specific transients showed the same central dominance but a significantly less pronounced midline dominance than the overall distribution pattern. Spatial extent was larger when ripples co-occurred with sleep-specific transients. Ripple rates during nonrapid eye movement (N) sleep stages N1 and N2 were higher than during N3 (T = 22.00, p = 0.02 and T = 23.00, p = 0.01).

CONCLUSIONS

Scalp-EEG recorded physiological ripples co-occur with various sleep-specific EEG-transients, especially with vertex waves. These ripples occur most frequently during light sleep.