绒毛膜绒毛镰状细胞贫血的DNA诊断：母体细胞污染的可能影响。
DNA-diagnosis of sickle cell anemia from chorionic villi: possible influence of maternal cell contamination.
作者信息
Oehme R, Jonatha W D, Horst J
出版信息
Hum Genet. 1986 Jun;73(2):186-7. doi: 10.1007/BF00291613.
PMID:3013757
Abstract
The admixture of maternal tissue is a possible hazard of prenatal diagnosis from chorionic villi. Therefore the tolerable degree of maternal DNA contamination in prenatal diagnosis of sickle cell anemia was investigated by mixing various amounts of DNA from HbS carriers with DNA from normal individuals and sickle cell anemia patients. The results indicate that lower rate of admixed maternal DNA does not prevent an exact direct DNA-diagnosis of sickle cell anemia.
摘要
母体组织的混入是绒毛膜绒毛产前诊断的一个潜在风险。因此，通过将不同量的镰状细胞贫血症携带者的DNA与正常个体和镰状细胞贫血症患者的DNA混合，研究了镰状细胞贫血症产前诊断中母体DNA污染的可容忍程度。结果表明，较低比例的母体DNA混入并不妨碍对镰状细胞贫血症进行准确的直接DNA诊断。
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