Ward R H, Modell B, Petrou M, Karagözlu F, Douratsos E
Br Med J (Clin Res Ed). 1983 May 14;286(6377):1542-4. doi: 10.1136/bmj.286.6377.1542.
Samples of chorionic villi were obtained in the first trimester by aspiration using a cannula passed transcervically under the guidance of real time ultrasound. In initial studies in 47 anaesthetised patients immediately before therapeutic abortion a method was developed giving a success rate of 89%. In 10 patients successful sampling was performed as an outpatient procedure without anaesthesia. In all, seven diagnostic procedures were undertaken and four of the five unaffected pregnancies continued. The technique of chorionic villous sampling using real time ultrasound is simple to learn and yields material for biochemical analysis and chromosomal study without the need for tissue culture. The exact obstetric risk, however, remains to be defined.
在妊娠早期，通过在实时超声引导下经宫颈插入套管抽吸获取绒毛膜绒毛样本。在对47例即将进行治疗性流产的麻醉患者进行的初步研究中，开发了一种成功率为89%的方法。在10例患者中，成功采样作为门诊手术在无麻醉情况下进行。总共进行了7次诊断程序，5例未受影响的妊娠中有4例继续妊娠。使用实时超声进行绒毛膜绒毛取样技术易于学习，无需组织培养即可获得用于生化分析和染色体研究的材料。然而，确切的产科风险仍有待确定。
