Department of Chemical and Biomolecular Engineering , University of Akron , Akron , Ohio 44325 , United States.
Department of Chemical Engineering , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.
Langmuir. 2019 Feb 5;35(5):1119-1125. doi: 10.1021/acs.langmuir.8b01444. Epub 2018 Aug 23.
This work reports a study of electropolymerization kinetics, film thickness, stability, and antifouling properties of polydopamine (PDA) and its three analogues: poly(3-(3,4-dihydroxyphenyl)-l-alanine) (PL-DOPA), poly(5-hydroxytryptophan) (PL-5-HTP), and poly(Adrenalin) (PAdrenalin). It was observed that the number of the hydroxyl groups on the benzene ring and the type (primary vs secondary) of amine group significantly affect the electropolymerization kinetics and thus the thickness of the obtained polymer films. Monomers with two hydroxyl groups (except Adrenalin) resulted in films that were thicker (∼10-15 nm) than the one with only one hydroxyl group (PL-5-HTP) (∼5-8 nm) under similar conditions. Adrenalin containing a secondary amino group could not be deposited onto the ITO substrate, while the other three compounds containing a primary amino group completely covered the ITO. The PDA films had better electrochemical stability than the other films. No film showed stable antifouling surfaces against protein.
这项工作研究了聚多巴胺（PDA）及其三种类似物（聚（3-（3,4-二羟基苯基）-L-丙氨酸）（PL-DOPA）、聚（5-羟色氨酸）（PL-5-HTP）和聚（肾上腺素）（PAdrenalin））的电聚合动力学、膜厚、稳定性和抗污性能。结果表明，苯环上的羟基数量和胺基的类型（伯胺与仲胺）对电聚合动力学有显著影响，从而影响所得到的聚合物膜的厚度。在相似条件下，具有两个羟基的单体（肾上腺素除外）得到的膜比只有一个羟基的单体（PL-5-HTP）（5-8nm）厚（约 10-15nm）。含有仲氨基的肾上腺素不能沉积到 ITO 基底上，而其他三种含有伯氨基的化合物完全覆盖了 ITO。PDA 薄膜具有比其他薄膜更好的电化学稳定性。没有一种薄膜对蛋白质具有稳定的抗污表面。
