Organ transplant center, First affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou 510080, PR China; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou 510080, PR China.
Division of general surgery, The Eastern Hospital of the First affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China.
Transplant Rev (Orlando). 2018 Oct;32(4):187-193. doi: 10.1016/j.trre.2018.07.002. Epub 2018 Jul 29.
B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance. Emerging evidence has demonstrated that Follicular T helper (Tfh) cells are key effectors to promote the proliferation and differentiation of B cells into antibody-producing plasmablasts and memory B cells. T-follicular regulatory (Tfr) cells are a recently recognized cell population that has a negative regulatory role on Tfh cells in the follicle, preventing incessant antibody production. It is still less clear how those humoral immunoreactive cells affect transplant rejection and allograft loss. This review focuses on the production and function of Tfr/Tfh cells in the transplant environment. Better understanding of the functions and mechanisms of Tfr/Tfh cells will help to design new strategies to prevent allograft rejection and prolong graft survival.
B 细胞在器官移植排斥和移植物抗宿主病（GVHD）的同种异体反应中起着至关重要的作用。在过去的十年中，人们已经充分认识到同种异体移植物中的 B 细胞浸润和新产生的供体特异性抗体（DSA）与严重的移植物排斥和丧失以及糖皮质激素抵抗密切相关。新出现的证据表明，滤泡辅助性 T 细胞（Tfh）是促进 B 细胞增殖和分化为产生抗体的浆母细胞和记忆 B 细胞的关键效应物。滤泡调节性 T 细胞（Tfr）是最近被识别的细胞群体，其在滤泡中对 Tfh 细胞具有负调节作用，防止无休止的抗体产生。这些体液免疫反应性细胞如何影响移植排斥和移植物丢失尚不清楚。本综述重点介绍了 Tfr/Tfh 细胞在移植环境中的产生和功能。更好地了解 Tfr/Tfh 细胞的功能和机制将有助于设计预防移植物排斥和延长移植物存活的新策略。
