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舒更葡糖钠致小儿患者过敏反应

Sugammadex-Induced Hypersensitivity Reaction in a Pediatric Patient.

作者信息

Çolak Alkin, Yılmaz Elif, Kıray Büşra Küçük

机构信息

Department of Anaesthesiology, Trakya University School of Medicine, Edirne, Turkey.

Department of Anaesthesiology, Edirne Sultan I. Murat Government Hospital, Edirne, Turkey.

出版信息

Turk J Anaesthesiol Reanim. 2018 Feb;46(1):66-68. doi: 10.5152/TJAR.2018.04696. Epub 2018 Feb 1.

DOI:10.5152/TJAR.2018.04696
PMID:30140504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5858893/
Abstract

We report a case of a 3-year-old boy who administered sugammadex and developed an allergic reaction several minutes after the administration. He developed an increase in airway pressures and a decrease in peripheral oxygen saturation; auscultation revealed widespread wheezing in the lungs. He was successfully treated with immediate administration of methylprednisolone, pheniramine, and theophylline. We assumed an allergic reaction to sugammadex based on the clinical condition of the patient.

摘要

我们报告一例3岁男孩,其在给予舒更葡糖钠后几分钟出现过敏反应。他出现气道压力升高和外周血氧饱和度下降;听诊显示双肺广泛哮鸣音。通过立即给予甲泼尼龙、苯海拉明和茶碱,他得到了成功治疗。基于患者的临床情况,我们推测为对舒更葡糖钠的过敏反应。

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Sugammadex-induced anaphylactic reaction: A systematic review.舒更葡糖钠引起的过敏反应:一项系统评价。
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J Anaesthesiol Clin Pharmacol. 2021 Apr-Jun;37(2):153-159. doi: 10.4103/joacp.JOACP_383_19. Epub 2021 Jul 15.

本文引用的文献

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Tracheal extubation in deeply anesthetized pediatric patients after tonsillectomy: a comparison of high-concentration sevoflurane alone and low-concentration sevoflurane in combination with dexmedetomidine pre-medication.扁桃体切除术后深度麻醉小儿患者的气管拔管:单纯高浓度七氟醚与低浓度七氟醚联合右美托咪定预处理的比较
BMC Anesthesiol. 2017 Feb 21;17(1):28. doi: 10.1186/s12871-017-0317-3.
2
Clinical pharmacology and efficacy of sugammadex in the reversal of neuromuscular blockade.舒更葡糖钠逆转神经肌肉阻滞的临床药理学及疗效
Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):1097-108. doi: 10.1080/17425255.2016.1215426. Epub 2016 Aug 3.
3
Sugammadex: A Review of Neuromuscular Blockade Reversal.苏伽达ex:神经肌肉阻滞逆转的综述。
Drugs. 2016 Jul;76(10):1041-52. doi: 10.1007/s40265-016-0604-1.
4
Three suspected cases of sugammadex-induced anaphylactic shock.三例疑似舒更葡糖钠所致过敏性休克病例。
BMC Anesthesiol. 2014 Oct 17;14:92. doi: 10.1186/1471-2253-14-92. eCollection 2014.
5
Hypersensitivity associated with sugammadex administration: a systematic review.与 sugammadex 给药相关的过敏反应:系统评价。
Anaesthesia. 2014 Nov;69(11):1251-7. doi: 10.1111/anae.12736. Epub 2014 May 22.
6
Sugammadex hypersensitivity-a case of anaphylaxis.舒更葡糖钠超敏反应——1例过敏反应病例
Anaesth Intensive Care. 2014 Jan;42(1):89-92. doi: 10.1177/0310057X1404200115.
7
Effects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.舒更葡糖钠对健康受试者活化部分凝血活酶时间和凝血酶原时间的影响。
Int J Clin Pharmacol Ther. 2014 Mar;52(3):227-36. doi: 10.5414/CP201976.
8
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Acta Anaesthesiol Taiwan. 2012 Dec;50(4):183-4. doi: 10.1016/j.aat.2012.08.010. Epub 2013 Jan 5.
9
Tracheal extubation of deeply anesthetized pediatric patients: a comparison of sevoflurane and sevoflurane in combination with low-dose remifentanil.深度麻醉小儿患者的气管拔管:七氟醚与七氟醚联合低剂量瑞芬太尼的比较
Paediatr Anaesth. 2012 Dec;22(12):1179-84. doi: 10.1111/j.1460-9592.2012.03906.x. Epub 2012 Jul 4.
10
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