Jeyadoss J, Kuruppu P, Nanjappa N, Van Wijk Rraw
Department of Anaesthesia, The Queen Elizabeth Hospital, South Australia, Australia.
Anaesth Intensive Care. 2014 Jan;42(1):89-92. doi: 10.1177/0310057X1404200115.
We describe a case of a patient undergoing open abdominal aneurysm surgery who developed a severe, life-threatening allergic reaction immediately after administration of sugammadex. The manifestation was purely a cardiovascular collapse. The mainstay of treatment was administration of high-dose adrenaline and fluid resuscitation. The diagnosis of anaphylaxis was supported by a positive serum mast cell tryptase (93 µg/l) at one hour post-event. Sugammadex was confirmed as the cause of the anaphylaxis by a positive intradermal allergy test (25 mm diameter response to 1:100 dilution), with a normal saline control and a negative response to the other drugs used during the event. This case report is a reminder that the use of sugammadex is associated with rare but serious risks.
我们描述了一例接受开放性腹主动脉瘤手术的患者，在给予舒更葡糖后立即发生了严重的、危及生命的过敏反应。表现为单纯的心血管虚脱。治疗的主要方法是给予高剂量肾上腺素和液体复苏。事件发生后1小时血清肥大细胞类胰蛋白酶阳性（93μg/l）支持过敏反应的诊断。通过皮内过敏试验阳性（对1:100稀释液的直径为25mm的反应）证实舒更葡糖是过敏反应的原因，生理盐水对照为阴性反应，对事件期间使用的其他药物反应也为阴性。本病例报告提醒人们，使用舒更葡糖会有罕见但严重的风险。
