UC Irvine School of Medicine , Irvine , California , USA.
Gavin Herbert Eye Institute , Irvine , California , USA.
Ocul Immunol Inflamm. 2019;27(7):1124-1126. doi: 10.1080/09273948.2018.1497666. Epub 2018 Aug 24.
: To describe a case of granulomatous anterior uveitis and histologically confirmed chronic granulomatous conjunctivitis in the presence of common variable immune deficiency (CVID). : Interventional case report. : A 72-year-old female with a history of CVID treated with regular intravenous immunoglobulin (IVIG) infusions developed chronic conjunctivitis and granulomatous anterior uveitis. She responded to topical steroids, but there was recurrence upon cessation of steroid therapy. Conjunctival biopsy demonstrated micro-granulomas in the stroma and epithelium. Treatment with IVIG was maintained throughout. : Although rare, a diagnosis of CVID should be considered in patients with recurrent conjunctivitis and uveitis of unknown etiology, especially if there is a clinical history suggestive of defective immunity. They tend to respond well to continued steroid therapy, and IVIG therapy should not be stopped.
: 描述 1 例在普通可变免疫缺陷 (CVID) 存在的情况下出现肉芽肿性前葡萄膜炎和组织学证实的慢性肉芽肿性结膜炎。 : 介入性病例报告。 : 1 例 72 岁女性，患有 CVID，接受常规静脉免疫球蛋白 (IVIG) 输注治疗，出现慢性结膜炎和肉芽肿性前葡萄膜炎。她对局部皮质类固醇有反应，但在停止皮质类固醇治疗后复发。结膜活检显示基质和上皮中的微肉芽肿。整个过程中均采用 IVIG 治疗。 : 尽管罕见，但对于病因不明的复发性结膜炎和葡萄膜炎患者，如果有提示免疫缺陷的临床病史，应考虑 CVID 的诊断。它们往往对持续的皮质类固醇治疗反应良好，不应停止 IVIG 治疗。
