Slizgi G R, Ludens J H
Life Sci. 1986 Jun 30;38(26):2437-40. doi: 10.1016/0024-3205(86)90613-2.
Kappa opioids produce diuresis presumably through ADH. We investigated further the role of ADH in kappa-induced diuresis by utilizing the Brattleboro rat, a strain lacking endogenous ADH. Ethylketocyclazocine (EKC), a kappa opioid prototype, increased urine formation in Sprague-Dawley, but not in Brattleboro rats. Furthermore, EKC pretreatment abolished the antidiuretic response to ADH administered exogenously to Brattleboro rats. Our study suggests that, in addition to a fall in plasma ADH reported previously, kappa opioids have direct effects on the renal response to ADH.
κ阿片类药物可能通过抗利尿激素（ADH）产生利尿作用。我们利用遗传性尿崩症大鼠（一种缺乏内源性抗利尿激素的品系）进一步研究了抗利尿激素在κ阿片类药物诱导的利尿作用中的作用。κ阿片类药物原型乙基酮环唑辛（EKC）增加了斯普拉格-道利大鼠的尿液生成，但对遗传性尿崩症大鼠没有此作用。此外，EKC预处理消除了遗传性尿崩症大鼠对外源性给予抗利尿激素的抗利尿反应。我们的研究表明，除了先前报道的血浆抗利尿激素水平下降外，κ阿片类药物对肾脏对抗利尿激素的反应有直接影响。
