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粘连性小肠梗阻中与肠绞窄性梗阻及复发相关的临床因素:一项对288例病例的回顾性研究

Clinical factors associated with intestinal strangulating obstruction and recurrence in adhesive small bowel obstruction: A retrospective study of 288 cases.

作者信息

Mu Jian-Feng, Wang Quan, Wang Shi-Dong, Wang Chuan, Song Jia-Xing, Jiang Jing, Cao Xue-Yuan

机构信息

Department of Gastric and Colorectal and Anal Surgery Division of Clinical Research Clinical Laboratory, The First Hospital of Jilin University, Changchun, Jilin Province, China.

出版信息

Medicine (Baltimore). 2018 Aug;97(34):e12011. doi: 10.1097/MD.0000000000012011.

Abstract

Postoperative adhesions are a common cause of adhesive small bowel obstruction (ASBO), and recognition of intestinal strangulation is important. The aim of this study is to analyze the clinical factors for strangulating obstruction and to identify the predictors for recurrence of ASBO.A retrospective study was conducted using the database in our department. Patients with ASBO from January 2013 to April 2016 were included in the study and were subject to follow-up. The clinical factors associated with strangulating obstruction and recurrence after treatment were analyzed by using univariate and multivariate logistic regression model.In total, 288 ASBO patients were included in the study. Of these, 37 (12.9%) patients had occurred strangulating obstructions, and 251 (87.1%) patients had simple obstructions. Four clinical parameters, including increasing heart rate (>100 bpm), increasing WBC count (>15 × 10/L), CT findings of thickening or swelling of the mesentery, and CT showing seroperitoneum were detected as independent clinical factors for intestinal strangulation. Eighty-four (29.2%) patients experienced recurrence of obstruction during the median 24 months of follow-up. Recurrence rates were reduced in patients who underwent surgical treatment compared with those who received conservative management [21.3% (26/122) vs 34.9% (58/166) (P = .010)]. Nevertheless, the recurrence rates were not significantly increased in patients with strangulating obstructions compared with those with simple ASBO [34.3% (12/35) vs 27.7% (72/253) (P = .186)].Four clinical parameters including tachycardia, leukocytosis, along with CT findings of thickening or swelling of the mesentery and CT showing seroperitoneum, associated with occurrence of intestinal strangulation in ASBO. ASBO patients who underwent surgical treatment had a reduced recurrence rate, but ASBO patients with strangulating obstructions had not increase the recurrence rates than those of patients with simple ASBO.

摘要

术后粘连是粘连性小肠梗阻(ASBO)的常见原因,识别肠绞窄很重要。本研究的目的是分析绞窄性梗阻的临床因素,并确定ASBO复发的预测因素。使用我科数据库进行了一项回顾性研究。纳入2013年1月至2016年4月期间患有ASBO的患者并进行随访。采用单因素和多因素逻辑回归模型分析与绞窄性梗阻及治疗后复发相关的临床因素。

本研究共纳入288例ASBO患者。其中,37例(12.9%)患者发生绞窄性梗阻,251例(87.1%)患者为单纯性梗阻。检测到四个临床参数,包括心率加快(>100次/分钟)、白细胞计数增加(>15×10⁹/L)、肠系膜增厚或肿胀的CT表现以及CT显示腹腔积液,这些是肠绞窄的独立临床因素。在中位24个月的随访期间,84例(29.2%)患者出现梗阻复发。与接受保守治疗的患者相比,接受手术治疗的患者复发率降低[21.3%(26/122)对34.9%(58/166)(P = 0.010)]。然而,与单纯ASBO患者相比,绞窄性梗阻患者的复发率并未显著增加[34.3%(12/35)对27.7%(72/253)(P = 0.186)]。

四个临床参数,包括心动过速、白细胞增多,以及肠系膜增厚或肿胀的CT表现和CT显示腹腔积液,与ASBO中肠绞窄的发生有关。接受手术治疗的ASBO患者复发率降低,但绞窄性梗阻的ASBO患者与单纯ASBO患者相比,复发率并未增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea8/6112878/92cfcf1ebae2/medi-97-e12011-g002.jpg

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