Li Jie, Zhang Bo, Yang Yan Fang, Jin Jian, Liu Yong Hong
Thyroid and Breast Surgery Anesthesiology Department, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe Qu, Cangzhou, China.
Medicine (Baltimore). 2018 Aug;97(34):e12056. doi: 10.1097/MD.0000000000012056.
Many reports suggest that aldehyde dehydrogenase 1 (ALDH1) expression is associated with poorer neoadjuvant chemotherapy (NAC) response in patients with breast cancer; however, the prognostic value of this enzyme in cancer has yet to be confirmed. Therefore, we conducted a meta-analysis of related studies to investigate the relationship between ALDH1 expression and the NAC response in breast cancer patients.
PubMed, Web of Science, ScienceDirect, Cochrane Library, and EMBASE were searched for potentially eligible literature. The study characteristics and relevant data were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of ALDH1 in the NAC response in patients with breast cancer. The robustness of our results was confirmed by sensitivity and publication bias analyses.
Pooled meta-analysis of 10 eligible studies including 1081 patients indicated an association between high ALDH1 expression and poor NAC responses (pooled OR = 0.44, 95% CI: 0.25-0.77, P = .004) with low significant heterogeneity (I = 55.1%, P = .018). During subgroup analyses, we found that the recipient sample size presents a potential source of heterogeneity. Begg funnel plot and Egger test showed no possible publication bias. Sensitivity analysis suggested that the pooled OR was robust.
Our results suggested that higher ALDH1 expression is associated with poorer NAC responses in patients with breast cancer. However, given the limited number of studies analyzed in this work, more studies are necessary to verify our results.
许多报告表明，醛脱氢酶1（ALDH1）的表达与乳腺癌患者新辅助化疗（NAC）反应较差有关；然而，这种酶在癌症中的预后价值尚未得到证实。因此，我们进行了一项相关研究的荟萃分析，以探讨ALDH1表达与乳腺癌患者NAC反应之间的关系。
检索PubMed、Web of Science、ScienceDirect、Cochrane图书馆和EMBASE，查找可能符合条件的文献。提取研究特征和相关数据。汇总具有95%置信区间（CI）的比值比（OR），以评估ALDH1在乳腺癌患者NAC反应中的预后作用。通过敏感性和发表偏倚分析证实了我们结果的稳健性。
对包括1081例患者的10项符合条件的研究进行汇总荟萃分析，结果表明ALDH1高表达与NAC反应较差之间存在关联（汇总OR = 0.44，95% CI：0.25 - 0.77，P = 0.004），异质性较低（I = 55.1%，P = 0.018）。在亚组分析中，我们发现接受者样本量是异质性的一个潜在来源。Begg漏斗图和Egger检验显示不存在可能的发表偏倚。敏感性分析表明汇总OR是稳健的。
我们的结果表明，ALDH1表达较高与乳腺癌患者NAC反应较差有关。然而，鉴于本研究分析的研究数量有限，需要更多研究来验证我们的结果。
