Chen Xiaofeng, Qiu Xia, Hou Minghong, Wu Xiaotian, Dong Yahao, Ma Yansong, Yang Lijun, Wei Yuping
Department of Chemistry, School of Science , Tianjin University , Tianjin 300354 , P. R. China.
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine , Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , P. R. China.
Langmuir. 2019 Feb 5;35(5):1475-1482. doi: 10.1021/acs.langmuir.8b01869. Epub 2018 Sep 5.
Zwitterionic sulfobetaine (SB) and carboxybetaine (CB) have been extensively investigated for their noticeable antifouling properties. Both SB and CB have cationic and anionic groups in the molecule, but they differ in negatively charged groups. Molecular simulations have been conducted to investigate the different properties induced by structure changes. However, few studies have focused on the differences between SB and CB materials, especially zwitterionic polysaccharides. Two zwitterionic sulfobetaine and carboxybetaine dextran hydrogels were designed and used as models to compare their properties. Results showed that the equilibrium swelling ratios of the SB-DEX hydrogels were much higher than CB-DEX ones, and larger interior pores were observed in the SB-DEX hydrogels due to their higher hydrophilicity. The rheological storage modulus of the SB-DEX hydrogels was lower than that of CB-DEX ones as a result of higher water content of SB-DEX. These results were consistent with molecular modeling. Additionally, both CB-DEX and SB-DEX had remarkable biocompatibilities, and the in vitro release studies showed that the SB-DEX and CB-DEX hydrogels released DOX in a sustained manner under acidic condition (pH 5.0), indicating their promise as an effective drug-delivery system.
两性离子磺基甜菜碱（SB）和羧基甜菜碱（CB）因其显著的防污性能而受到广泛研究。SB和CB分子中均含有阳离子和阴离子基团，但它们的负电荷基团有所不同。已进行分子模拟以研究结构变化引起的不同性质。然而，很少有研究关注SB和CB材料之间的差异，尤其是两性离子多糖。设计了两种两性离子磺基甜菜碱和羧基甜菜碱葡聚糖水凝胶并将其用作模型来比较它们的性质。结果表明，SB-DEX水凝胶的平衡溶胀率远高于CB-DEX水凝胶，并且由于其较高的亲水性，在SB-DEX水凝胶中观察到更大的内部孔隙。由于SB-DEX含水量较高，其流变储能模量低于CB-DEX。这些结果与分子模拟一致。此外，CB-DEX和SB-DEX均具有显著的生物相容性，体外释放研究表明，SB-DEX和CB-DEX水凝胶在酸性条件（pH 5.0）下以持续方式释放阿霉素，表明它们有望成为有效的药物递送系统。
