Universidade de São Paulo (USP), Hospital Universitário (HU), São Paulo, SP, Brazil.
Universidade de São Paulo (USP), Hospital Universitário (HU), São Paulo, SP, Brazil; Hospital Infantil Sabará, São Paulo, SP, Brazil.
Braz J Otorhinolaryngol. 2019 Nov-Dec;85(6):746-752. doi: 10.1016/j.bjorl.2018.07.004. Epub 2018 Aug 8.
The use of saline irrigation for nasal washes is a well established procedure in the treatment of sinonasal inflammation and infection. In addition to saline solutions, Ringer's lactate is also an efficient option for nasal washes and humidification.
To assess the comfort, humidification and tolerance regarding stinging sensation, provided by sodium chloride nasal gel at the concentrations of 4.5mg/g and 6.0mg/g through questionnaires answered by the patients.
A total of 60 patients, 56 females, aged between 22 and 66 years old (mean age of 47) and 4 males, aged between 36 and 66 years (mean age of 49), were included in the study for a period of 17 days (±2 days) treatment. The patients were monitored by a general practitioner throughout the study period. They were instructed to apply each product in both nostrils twice a day during a 7-day period (±2 days). The patients were evaluated prior to the use of the first product at visit 0 (V0), after 7 days of treatment (±2 days) at visit 1 (V1), after 3 days of product discontinuation at visit 2 (V2) and after 7 days (±2 days) of treatment with the second product, in visit 3 (V3).
A significant difference (5% significance) was observed regarding comfort and stinging sensation between the two different concentrations; comfort was higher and stinging was lower with the 6.0mg/g concentration gel. No difference in humidification was observed between the two treatments.
Ringer's lactate at the concentration of 6.0mg/g was superior to that at 4.5mg/g for parameters comfort and stinging sensation. No statistical difference was observed between the two products regarding nasal humidification.
盐水冲洗鼻腔是治疗鼻-鼻窦炎症和感染的常用方法。除盐水溶液外，乳酸林格氏液也是鼻腔冲洗和加湿的有效选择。
通过患者回答的问卷评估 4.5mg/g 和 6.0mg/g 氯化钠鼻腔凝胶在舒适度、加湿和刺痛感方面的差异。
共有 60 名患者（56 名女性，年龄 22-66 岁，平均年龄 47 岁；4 名男性，年龄 36-66 岁，平均年龄 49 岁）参与了为期 17 天（±2 天）的研究。在整个研究期间，患者由一名全科医生进行监测。他们被指示在 7 天（±2 天）内每天在两个鼻孔中使用每种产品两次。在使用第一种产品前（访视 0，V0）、治疗 7 天后（±2 天，V1）、停药 3 天后（访视 2，V2）以及使用第二种产品治疗 7 天后（±2 天，V3），对患者进行评估。
两种不同浓度之间在舒适度和刺痛感方面观察到显著差异（5%显著水平）；6.0mg/g 浓度凝胶的舒适度更高，刺痛感更低。两种治疗方法在加湿方面无差异。
对于舒适度和刺痛感这两个参数，6.0mg/g 浓度的乳酸林格氏液优于 4.5mg/g 浓度的氯化钠凝胶。两种产品在鼻腔加湿方面无统计学差异。
