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骨髓来源的单个核细胞移植后脊柱裂患者肠道功能改善：2例报告

Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases.

作者信息

Liem Nguyen Thanh, Chinh Vu Duy, Thinh Nguyen Thi, Minh Ngo Duy, Duc Hoang Minh

机构信息

Stem Cell and Immune Cell Department, Vinmec Research Institute of Stem Cell and Gene Technology, Times City, Ha Noi, Vietnam.

Center for Excellence for Autism and Cerebral Palsy, Vinmec International Hospital, Times City, Ha Noi, Vietnam.

出版信息

Am J Case Rep. 2018 Aug 25;19:1010-1018. doi: 10.12659/AJCR.909801.

DOI:10.12659/AJCR.909801
PMID:30143601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6120349/
Abstract

BACKGROUND Bowel dysfunction is observed in 42.2-71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation. CASE REPORT Two patients - 14 years old and 11 years old - with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively. CONCLUSIONS BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.

摘要

背景

在42.2%至71.2%的脊柱裂患者中观察到肠道功能障碍。传统治疗效果有限。本文的目的是报告2例脊柱裂患儿在接受骨髓来源的单个核细胞移植后肠道功能的改善情况。病例报告：两名患者，分别为14岁和11岁，在脊髓脊膜膨出修补术后出现肠道功能障碍，接受了2次骨髓单个核细胞移植，无并发症发生。通过分别为期21个月和16个月的随访评估，这些患者排便正常。结论：如2例脊柱裂患者所示，骨髓单个核细胞移植可改善肠道功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/0b181e87ee07/amjcaserep-19-1010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/85a42bbe83c0/amjcaserep-19-1010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/6403e06e27c8/amjcaserep-19-1010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/6d4a4a554cf9/amjcaserep-19-1010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/8ab2358089c5/amjcaserep-19-1010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/bb7de6e3dd14/amjcaserep-19-1010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/afcb95c38515/amjcaserep-19-1010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/42ea634e66e2/amjcaserep-19-1010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/0b181e87ee07/amjcaserep-19-1010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/85a42bbe83c0/amjcaserep-19-1010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/6403e06e27c8/amjcaserep-19-1010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/6d4a4a554cf9/amjcaserep-19-1010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/8ab2358089c5/amjcaserep-19-1010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/bb7de6e3dd14/amjcaserep-19-1010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/afcb95c38515/amjcaserep-19-1010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/42ea634e66e2/amjcaserep-19-1010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/6120349/0b181e87ee07/amjcaserep-19-1010-g008.jpg

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