Medical School, University College London, London, UK.
Rheumatology Department, Nicosia General Hospital, Nicosia-Limassol, Old Road No. 215, 2029, Nicosia, Cyprus.
Rheumatol Int. 2019 Jul;39(7):1285-1289. doi: 10.1007/s00296-018-4145-7. Epub 2018 Aug 24.
Mesenteric panniculitis (MP) is a rare chronic disease characterized by inflammation and subsequently fibrosis of adipose tissue of the omentum. Only recently it has been associated with IgG4-related disease. Cancer antigen 125 (CA-125) is a high-molecular mass glycoprotein, traditionally associated with ovarian cancer, although it can be elevated in other conditions. Herein we describe a case of a 56-year-old man with IgG4 related mesenteric panniculitis associated with very high levels of CA-125 at the onset of disease. The CA-125 levels corresponded to clinical disease activity and improved with steroid therapy and rituximab. A literature review was performed concerning possible association of MP, IgG4-related disease and CA-125. The review of literature suggests that high levels of CA-125 can be raised in non-malignant, inflammatory conditions including IgG4-related mesenteritis and can improve with treatment.
肠系膜脂膜炎（MP）是一种罕见的慢性疾病，其特征为网膜脂肪组织的炎症和随后的纤维化。最近才与 IgG4 相关疾病相关联。癌抗原 125（CA-125）是一种高分子质量糖蛋白，传统上与卵巢癌相关，尽管它在其他情况下也可能升高。本文描述了一例 56 岁男性 IgG4 相关肠系膜脂膜炎，在疾病发作时 CA-125 水平非常高。CA-125 水平与临床疾病活动度相对应，且在类固醇治疗和利妥昔单抗治疗后改善。对可能与 MP、IgG4 相关疾病和 CA-125 相关的文献进行了回顾。文献回顾表明，在非恶性炎症性疾病中，包括 IgG4 相关肠系膜炎，CA-125 水平可能升高，并可随治疗而改善。
