Palacios J M, Reubi J C, Maurer R
Neurosci Lett. 1986 Jun 18;67(2):169-74. doi: 10.1016/0304-3940(86)90392-7.
The effect of neurotoxic chemical and electrolytical lesions on somatostatin (SS) receptor binding in the septo-hippocampal afferents, pyramidal and granule cells of the rat hippocampus was examined by autoradiography using the stable SS analogue 125I-204-090 as radioligand. Electrolytical lesions of the septum did not result in modification of SS binding in the hippocampus. In contrast, both granule cell lesion with colchicine and pyramidal or pyramidal and granule cell lesions with increasing kainic acid doses did result in a specific decrease of binding in the dentate gyrus and hippocampus (CA1 and CA3). These results suggest that SS receptors in the hippocampus are probably associated with elements from intrinsic neurons.
采用稳定的生长抑素（SS）类似物125I - 204 - 090作为放射性配体，通过放射自显影术研究了神经毒性化学损伤和电解损伤对大鼠海马中隔 - 海马传入纤维、锥体细胞和颗粒细胞中SS受体结合的影响。隔区的电解损伤并未导致海马中SS结合的改变。相反，秋水仙碱导致的颗粒细胞损伤以及用递增剂量的 kainic 酸导致的锥体细胞或锥体细胞与颗粒细胞损伤，均导致齿状回和海马（CA1和CA3）中结合特异性降低。这些结果表明，海马中的SS受体可能与内在神经元的成分相关。
