维生素 D 的免疫调节作用：综述。

Immunomodulatory Role of Vitamin D: A Review.

机构信息

Student's Scientific Group at Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.

Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.

出版信息

Adv Exp Med Biol. 2018;1108:13-23. doi: 10.1007/5584_2018_246.

DOI:10.1007/5584_2018_246

PMID:30143987

Abstract

Vitamin D is well known for its classical hormonal action related to the maintenance of mineral and skeletal homeostasis. However, the discovery that vitamin D receptor (VDR) is expressed in most non-skeletal tissues points to its broad role in the human organism. Current literature emphasizes a multidirectional role of vitamin D, with a special focus on its immunomodulatory properties. As VDR and the enzyme 1-α-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells. In addition, it induces the microbicidal activity of phagocytes. In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells. In this review we aimed to describe the current scientific discoveries on the role of vitamin D as immunomodulator.

摘要

维生素 D 以其与矿物质和骨骼内稳态维持有关的经典激素作用而闻名。然而，维生素 D 受体 (VDR) 在大多数非骨骼组织中表达的发现表明其在人体中具有广泛的作用。目前的文献强调了维生素 D 的多向作用，特别关注其免疫调节特性。由于 VDR 和 1-α-羟化酶在大多数免疫细胞中表达，维生素 D 调节巨噬细胞和自然杀伤细胞的吞噬活性。此外，它诱导吞噬细胞的杀菌活性。相反，维生素 D 抑制抗原呈递树突状细胞和 B 淋巴细胞的分化和成熟，并抑制 Th1 和 Th17 细胞的增殖。在这篇综述中，我们旨在描述维生素 D 作为免疫调节剂的当前科学发现。